Development of a quantification method for the quality control of a novel water soluble substance, рotassium (3-(4-hydroxy-3,5-dimethylbenzylthio) propionate(TF-7)
- Authors: Mukundwi W.Т.1, Terentyeva S.V.1,2, Ligostaev А.V.1, Ivanovskaya Е.А.1, Kandlintseva N.V.2, Oleynik А.S.2
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Affiliations:
- Novosibirsk State Medical University
- Novosibirsk State Pedagogical University
- Issue: Vol 28, No 6 (2025)
- Pages: 99-108
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/685731
- DOI: https://doi.org/10.29296/25877313-2025-06-13
- ID: 685731
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Abstract
Introduction. One of the promising directions of antioxidant chemistry development is the synthesis and study of specific activity of organic compounds based on sulphur. The most active research in this area is carried out at the Department of Chemistry of FSBI HE Novosibirsk State Pedagogical University together with the Research Institute of Antioxidant Chemistry.
Aim – to select and study the spectrophotometric and titrimetric characteristics of sulfur-containing water-soluble antioxidant TF-7 and compare them.
Material and Methods. In this study, the spectrophotometric characteristics of a novel water-soluble antioxidant, TF-7 (3-(4-hydroxy-3,5-dimethylbenzylthio)potassium propionate), were investigated. A spectrophotometric methodology was employed for the purposes of quantitative and qualitative analysis. The titrimetric methods of acidimetry, iodometry and mercurimetry were selected for comparative analysis of the new substance TF-7.
Results. The preliminary studies indicated that the spectrophotometric analysis of the pharmaceutical substance in the ultraviolet (UV) spectrum exhibited a maximum at a wavelength of 276 ± 2 nanometres (nm). The mercurimetry method was identified as the most accurate of the selected titrimetric methods for the determination of TF-7, with an equation of y=1,014895x+0,0000001 and a correlation coefficient of 0.9996.
Сonclusion. The characterisation of spectrophotometric and titrimetric methods of analysis for the quantification of the new substance TF-7 has been developed. It has been demonstrated that the aforementioned methods of obtaining qualitative and quantitative characteristics for spectrophotometric determination and mercurimetry titration are optimal for analysis in model solutions.
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About the authors
W. Т. Mukundwi
Novosibirsk State Medical University
Author for correspondence.
Email: willardmkundwi@gmail.com
ORCID iD: 0009-0005-6654-7185
Post-graduate Student, Department of Pharmaceutical Chemistry
Russian Federation, Krasny Prospect 52, Novosibirsk, 630091S. V. Terentyeva
Novosibirsk State Medical University; Novosibirsk State Pedagogical University
Email: willardmkundwi@gmail.com
ORCID iD: 0000-0003-3566-2760
SPIN-code: 6439-9850
Dr.Sc. (Pharm.), Professor of the Department of Pharmaceutical Chemistry; Professor of the Department of Chemistry
Russian Federation, Krasny Prospect 52, Novosibirsk, 630091; Vilyuyskaya st., 28, Novosibirsk, 630126А. V. Ligostaev
Novosibirsk State Medical University
Email: willardmkundwi@gmail.com
ORCID iD: 0009-0002-0317-6944
Ph.D. (Pharm.), Associate Professor of the Department of Pharmaceutical Chemistry
Russian Federation, Krasny Prospect 52, Novosibirsk, 630091Е. А. Ivanovskaya
Novosibirsk State Medical University
Email: willardmkundwi@gmail.com
ORCID iD: 0000-0002-9338-5792
Dr.Sc. (Pharm.), Professor, Head of the Department of Pharmaceutical Chemistry
Russian Federation, Krasny Prospect 52, Novosibirsk, 630091N. V. Kandlintseva
Novosibirsk State Pedagogical University
Email: willardmkundwi@gmail.com
ORCID iD: 0000-0001-6022-934X
SPIN-code: 9814-7106
Dr.Sc. (Chem.), Associate Professor, Head of the Department of Chemistry
Russian Federation, Vilyuyskaya st., 28, Novosibirsk, 630126А. S. Oleynik
Novosibirsk State Pedagogical University
Email: willardmkundwi@gmail.com
ORCID iD: 0009-0007-1113-6682
SPIN-code: 8988-3870
Ph.D. (Chem.) Associate Professor of the Department of Chemistry
Russian Federation, Vilyuyskaya st., 28, Novosibirsk, 630126References
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