Study of acute toxicity of dry extract of Potentilla alba L

Purpose. Determine the toxicity parameters of the dry extract of Potentilla alba L. when administered once to laboratory animals. Methods. The acute toxicity of the dry extract of Potentilla alba L. has been studied in BALB/c mice and Wistar rats of both sexes by intraperitoneal and intragastric administration. Toxicity parameters had determined by the method of Litchfield and Wilcoxon. Results. With a single intraperitoneal injection of the dry extract of Potentilla alba L. mice and rats (males and females), the same type of acute intoxication had observed: motor agitation, grooming, shortness of breath, cyanosis of the auricles and tail. The first death of animals had registered for 2-3 days after administration of the extract and continued for the next two days. The following indicators of average lethal doses for intraperitoneal administration to mice had established: 160 ± 26 mg/kg (males) and 150 ± 30 mg/kg (females), rats - 260 ± 45 mg/kg (males) and 250 ± 68 mg/kg (females). With a single injection of the dry extract of Potentilla alba L. in the stomach, the LD50 indice for mice and rats increase 40-50 times as compared with intraperitoneal administration and amount to 10,700-12,000 mg/kg for rats and 7,600-8,300 mg/kg for mice. Conclusion. With a single intraperitoneal and intragastric administration to laboratory animals (mice, rats of both sexes) of the dry extract of Potentilla alba L. is of low toxicity.

Potentilla alba L, Potentilla alba L, dry extract, mice, rats, acute toxicity