X-ray fluorescence determination of silver in colloidal solutions
- Authors: Kolyabina E.S.1, Maksimova T.V.1, Pleteneva T.V.1, Syroeshkin A.V.1
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Affiliations:
- RUDN University
- Issue: Vol 26, No 4 (2023)
- Pages: 28-31
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/340938
- DOI: https://doi.org/10.29296/25877313-2023-04-05
- ID: 340938
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Abstract
Objective. To develop the basics of technology for X-ray fluorescence determination of silver in colloidal solutions.
Relevance. Silver preparations are interesting as an alternative to antibiotics. Сurrently on the pharmaceutical market there is a large number of silver-containing colloidal dietary supplements, 70% of which contain silver in ionic form. The energy dispersive method of X-ray fluorescence analysis is an express method without long-term sample preparation.
Materials and methods. Silver proteinate (~8% Ag), Sigma-Aldrich; ProtargolLor (P.J.S.C. “Pharmstandard”, Kursk); Sialor (J.S.C. RENEWAL®); Argitos colloidal silver (“Nanosphere”, Russia), Argent Colloidal (Nutri expert, France). Dual Laser Light Scattering 2D-DLS (Zetasizer Malvern). Energy dispersive spectrometer Shimadzu EDX-7000 (Japan); OriginLab Corporation, USA.
Results. The technology of the X-ray fluorescence determination of silver in colloidal solutions from various companies was described in this paper. The present study has exploited the energy dispersive spectrometer Shimadzu EDX-7000 (Japan). The fluorescence intensity at AgKα = 22.105 keV depends linearly on the silver concentration in the range of 0.01% - 1% according to the equation I = (5.1 ± 0.1) · СAg for silver nitrate and I = (1.64 ± 0.03) · CAg for silver proteinate, which is due to the effect of the organic matrix.
Conclusion. The new XRF method was applied for quality control of protargol and other Ag-containing drugs and parapharmaceuticals.
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About the authors
E. S. Kolyabina
RUDN University
Author for correspondence.
Email: ks.kolyabina@gmail.com
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry
Russian Federation, MoscowT. V. Maksimova
RUDN University
Email: ks.kolyabina@gmail.com
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical and Toxicological Chemistry
Russian Federation, MoscowT. V. Pleteneva
RUDN University
Email: ks.kolyabina@gmail.com
Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry
Russian Federation, MoscowA. V. Syroeshkin
RUDN University
Email: ks.kolyabina@gmail.com
Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and toxicological Chemistry
Russian Federation, MoscowReferences
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