Influence of Lophanthus chinensis dry extract on the morphofunctional state of Wistar rats the brain during long-term alcoholization
- Authors: Razuvaeva Y.G.1, Khaltagarova E.D.1,2, Toropova А.А.1, Markova К.V.1, Olennikov D.N.1
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Affiliations:
- Institute of General and Experimental Biology SB RAS
- Banzarov Buryat State University
- Issue: Vol 27, No 5 (2024)
- Pages: 65-71
- Section: Problems of experimental biology and medicine
- URL: https://journals.eco-vector.com/1560-9596/article/view/633141
- DOI: https://doi.org/10.29296/25877313-2024-05-08
- ID: 633141
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Abstract
The study purpose – to evaluate the effect of the Lophanthus chinensis dry extract on the Wistar rats brain morphofunctional state against the background of long-term alcoholization.
Material and methods. Alcohol intoxication was induced by long-term administration (6 weeks) of 40% ethanol in rats. Lophanthus chinensis dry extract at a dose of 100 mg/kg was administered from the 3rd week of the experiment. On days 42-45, the animals were tested in an "open field", an elevated plus maze, and they developed a conditioned passive avoidance reaction. After which a neurons pathomorphological study in the cerebral cortex was carried out.
Results. It has been established that L. chinensis dry extract exhibits a neuroprotective effect during long-term alcohol intoxication, preventing the development of structural disorders in the cerebral cortex, thereby reducing anxiety and emotionality in animals, enhancing orientation-exploratory activity and normalizing mnestic functions.
Conclusion. L. chinensis dry extract has a neuroprotective effect during long-term alcohol intoxication.
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About the authors
Ya. G. Razuvaeva
Institute of General and Experimental Biology SB RAS
Author for correspondence.
Email: tatur75@mail.ru
Dr.Sc. (Biol.), Senior Research Scientist
Russian Federation, Ulan-Ude, Republic of BuryatiaE. D. Khaltagarova
Institute of General and Experimental Biology SB RAS; Banzarov Buryat State University
Email: haltik@yandex.ru
Post-graduate Student, Lecturer
Russian Federation, Ulan-Ude, Republic of Buryatia; Ulan-Ude, Republic of BuryatiaА. А. Toropova
Institute of General and Experimental Biology SB RAS
Email: anyuta-tor@mail.ru
Ph.D. (Biol.), Senior Research Scientist
Russian Federation, Ulan-Ude, Republic of BuryatiaК. V. Markova
Institute of General and Experimental Biology SB RAS
Email: kristen_kartland@mail.ru
Ph.D. (Med.), Senior Research Scientist
Russian Federation, Ulan-Ude, Republic of BuryatiaD. N. Olennikov
Institute of General and Experimental Biology SB RAS
Email: tatur75@mail.ru
Dr.Sc. (Pharm.), Head laboratory
Russian Federation, Ulan-Ude, Republic of BuryatiaReferences
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