Choleretic effect of the complex plant supplement in experimental liver damage
- 作者: Ubeeva E.A.1, Malov V.A.2, Nikolaev S.M.3, Ubeeva I.P.1, Tyheeva N.A.1
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隶属关系:
- Banzarov Buryat State University
- I.M. Sechenov First Moscow State Medical University
- Siberian Branch of the Russian Academy of Sciences
- 期: 卷 26, 编号 10 (2023)
- 页面: 43-49
- 栏目: Problems of experimental biology and medicine
- URL: https://journals.eco-vector.com/1560-9596/article/view/622760
- DOI: https://doi.org/10.29296/25877313-2023-10-07
- ID: 622760
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Relevance. The search for supplements with choleretic activity is of great interest due to their detoxicant properties and possible hepatoprotective effect.
The aim of our study was to evaluate choleretic effect of the complex plant supplement comprised of Hypecoum erectum L.; Hedysarum dahuricum Turcz. ex B.Fedtsch.; Glycyrrhiza uralensis Fisch. ex DC.; Calendula officinalis L.; Scutellaria baicalensis Georgi. dry extracts.
Material and methods. The research was conducted on an animal model of acute liver damage induced by CCl4 in 84 albino Wistar rats. The studied complex plant supplement was researched in doses of 100mg/kg, 200 mg/kg and 300 mg/kg in the course of 14 days starting from the 2nd day of the experiment. Choleretic properties were evaluated by both the speed of bile secretion (mg/min) per 100 g of animal weight and the total amount of bile secreted during four hours of observation.
Results. It has been established that the use of the dry extract in tetrachloromethane hepatitis in white rats has a choleretic effect characterized by an increase in the rate of bile secretion, an increase in the amount of discharged bile and the growing concentration of bile acids.
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作者简介
E. Ubeeva
Banzarov Buryat State University
编辑信件的主要联系方式.
Email: ubeeva.ip@mail.ru
ORCID iD: 0000-0002-9835-2279
Ph.D. (Med.), Associate Professor
俄罗斯联邦, Ulan-UdeV. Malov
I.M. Sechenov First Moscow State Medical University
Email: valmalov@list.ru
ORCID iD: 0000-0002-6157-1654
Dr.Sc. (Med.), Professor
俄罗斯联邦, MoscowS. Nikolaev
Siberian Branch of the Russian Academy of Sciences
Email: tatur75@mail.ru
ORCID iD: 0000-0002-5833-7576
Dr.Sc. (Med.), Professor, Chif Research Scientist, Institute of General and Experimental Biology
俄罗斯联邦, Ulan-UdeI. Ubeeva
Banzarov Buryat State University
Email: ubeeva.ip@mail.ru
ORCID iD: 0000-0001-8206-8436
Dr.Sc. (Med.), Professor
俄罗斯联邦, Ulan-UdeN. Tyheeva
Banzarov Buryat State University
Email: tyhey@mail.ru
Ph.D. (Med.), Associate Professor
俄罗斯联邦, Ulan-Ude参考
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