Effects of Levetiracetam on the Content of Neurotransmitter Amino Acids in the Brain of Rats with the Audiogenic Epileptiform Siezures



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Abstract

The anticonvulsant action of novel antiepileptic drug levetiracetam (LVT) on the content of aspartate, glutamate, glycine, taurine and GABA in brain structures of Krushinsky-Molodkina (KM) rats were studied using HPLC/FD techniques. The treatment with LVT anticipated decrease of levels of glutamate, glycine and taurine produced by seizure attack. In medulla oblongata LVT prevented the elevation of GABA level induced by the audiogenic stress. Thus, the anticonvulsant action of LVT against audiogenic seizures is likely to be related to the normalizing effect upon the levels of both excitatory and inhibitory neurotransmitter amino acid in the frontal cortex and medulla oblongata of KM rats.

About the authors

Lyudmila Alekseevna Malikova

Email: ludmal2006@yandex.ru

Irina Borisovna Fedotova

Petr Mikhaylovich Klodt

Natal'ya Mikhaylovna Surina

Inga Igorevna Poletaeva

Vladimir Sergeevich Kudrin

Kirill Sergeevich Raevskiy

L A Malikova

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

I B Fedotova

Lomonosov State University

; Lomonosov State University

P M Klodt

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

N A Surina

Lomonosov State University

; Lomonosov State University

V S Kudrin

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

I I Poletaeva

Lomonosov State University

; Lomonosov State University

K S Rayevsky

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

Zakusov Institute of Pharmacology Russian Academy of Medical Sciences

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