Effects of Clomipramine on Mixed Anxiety/Depression State Produced by Chronic Social Defeat Stress in Male Mice
- Authors: Smagin D.A.1, Galyamina A.G.1, Bondar' N.P.1, Kudryavtseva N.N.1, Smagin DA2, Galyamina AG2, Bondar NP2, Kudryavtseva NN2
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Affiliations:
- Institute of Cytology and Genetics SD RAS
- Issue: Vol 11, No 1-2 (2011)
- Pages: 2666-2676
- Section: Articles
- URL: https://journals.eco-vector.com/1606-8181/article/view/322021
- DOI: https://doi.org/10.17816/phbn322021
- ID: 322021
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Abstract
Smagin DA, Galyamina AG, Bondar NP, Kudryavtseva NN. [
Effects of clomipramine on mixed anxiety/depression state produced by chronic social defeat stress in male mice].
Psychopharmacol Biol Narcol. 2011; 11(1-2).
Epub 14 June 2011. Russian.
BACKGROUND. Chronic social defeat stress in daily agonistic interactions leads to development of mixed anxiety/depression state in male mice. Paper aimed to study effects of clomipramine on psychoemotional state in these animals with point on level of anxiety and depression.
METHODS. Mixed anxiety/depression state was produced by chronic social defeat stress during 20 days in male mice. Clomipramine (20, 40 mg/kg, i/p, SIGMA) and saline were chronically injected to chronically defeated mice during 2 weeks without agonistic interactions. After resting period the male mice were investigated in the partition, plus-maze and Porsolt' tests.
RESULTS. Clomipramine in dose 40 mg/kg decreased communicativeness in the partition test, produced anxiogenic effects and decreased exploratory activity in the plus-maze test and had antidepressive effect in the Porsolt' test. Clomipramine in dose 20 mg/kg had weak antidepressant effect and did not affect enhanced level of anxiety.
CONCLUSION. Clomipramine produces anxiogenic and antidepressant effects on mixed anxiety/depression state in male mice. It is supposed, that clomipramine, at least in dose of 40 mg/kg, may independently influence on anxiety and depression states.
Date submitted: March 22, 2011; Accepted: June 14, 2011.
Citation: Psychopharmacol Biol Narcol. 2011;11(1-2):2666-2676
Effects of clomipramine on mixed anxiety/depression state produced by chronic social defeat stress in male mice].
Psychopharmacol Biol Narcol. 2011; 11(1-2).
Epub 14 June 2011. Russian.
BACKGROUND. Chronic social defeat stress in daily agonistic interactions leads to development of mixed anxiety/depression state in male mice. Paper aimed to study effects of clomipramine on psychoemotional state in these animals with point on level of anxiety and depression.
METHODS. Mixed anxiety/depression state was produced by chronic social defeat stress during 20 days in male mice. Clomipramine (20, 40 mg/kg, i/p, SIGMA) and saline were chronically injected to chronically defeated mice during 2 weeks without agonistic interactions. After resting period the male mice were investigated in the partition, plus-maze and Porsolt' tests.
RESULTS. Clomipramine in dose 40 mg/kg decreased communicativeness in the partition test, produced anxiogenic effects and decreased exploratory activity in the plus-maze test and had antidepressive effect in the Porsolt' test. Clomipramine in dose 20 mg/kg had weak antidepressant effect and did not affect enhanced level of anxiety.
CONCLUSION. Clomipramine produces anxiogenic and antidepressant effects on mixed anxiety/depression state in male mice. It is supposed, that clomipramine, at least in dose of 40 mg/kg, may independently influence on anxiety and depression states.
Date submitted: March 22, 2011; Accepted: June 14, 2011.
Citation: Psychopharmacol Biol Narcol. 2011;11(1-2):2666-2676
Keywords
About the authors
Dmitriy Aleksandrovich Smagin
Anna Georgievna Galyamina
Natal'ya Petrovna Bondar'
Nataliya Nikolaevna Kudryavtseva
Email: n.n.kudryavtseva@gmail.com
D A Smagin
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
A G Galyamina
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
N P Bondar
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
N N Kudryavtseva
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
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