MicroRNA-30a-5p as a target for pharmacological correction of pathological conditions of the nervous system

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In the brain, the main inducers of neuroinflammation are proinflammatory cytokines, chemokines, reactive oxygen species and other mediators produced by microglia, astrocytes and endothelial cells. Chronic neuroinflammatory conditions are manifested by the infiltration of peripheral immune cells through the blood-brain barrier and cause tissue damage in the central nervous system, promoting glial activation and increasing the permeability of the blood-brain barrier. According to a number of studies, one of the regulators of these processes is small non-coding RNA, or microRNA, which can either contribute to disease progression or, conversely, reflect an attempt by the nervous system to prevent excessive damage and restore homeostasis. Studying the role of microRNA. miR-30a-5p among others, in these processes can shed light on the pathogenetic mechanisms underlying a number of neurological diseases and lead to the discovery of new therapeutic agents. In this review, we discuss the role of miR-30a-5p in the regulation of pro- and anti-inflammatory cytokine gene expression, possible mechanisms of its action, and the use of miR-30a-5p as a potential therapeutic target for pharmacological correction of neuroinflammation in pathological conditions of the nervous system.

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作者简介

Marat Airapetov

Institute of Experimental Medicine; Kirov Military Medical Academy

编辑信件的主要联系方式.
Email: interleukin1b@gmail.com
ORCID iD: 0000-0002-8318-9069
SPIN 代码: 5982-4075

MD, Cand. Sci. (Medicine), Assistant Professor

俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022; 6, Akademika Lebedeva st., Saint Petersburg, 194044

Sergei Eresko

Institute of Experimental Medicine; North-West State Medical University named after I.I. Mechnikov

Email: eresko.sergei@yandex.ru
ORCID iD: 0000-0002-0269-6078
SPIN 代码: 4096-2798
俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022; 41, Kirochnaya st. 191015 Saint Petersburg

Sofiya Shamayeva

Institute of Experimental Medicine

Email: interleukin1b@gmail.com
俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022

Andrei Lebedev

Institute of Experimental Medicine

Email: aalebedev-iem@rambler.ru
ORCID iD: 0000-0003-0297-0425
SPIN 代码: 4998-5204

MD, Dr. Sci. (Biology), Professor

俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022

Evgenii Bychkov

Institute of Experimental Medicine

Email: bychkov@mail.ru
ORCID iD: 0000-0002-8911-6805
SPIN 代码: 9408-0799

Dr. Sci. (Medicine)

俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022

Petr Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127
SPIN 代码: 8974-7477

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 12, Akademika Pavlova st., Saint Petersburg, 197022

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