Vol 10, No 1-2 (2010)

Articles

Development of Autistic Spectrum Symptoms under Chronic Social Defeat Stress in Anxious Male Mice: Effects of Diazepam

Kovalenko I.L., Kudryavtseva N.N., Kovalenko I.L., Kudryavtseva N.N.

Abstract

Kovalenko IL, Kudryavtseva NN. [Development of autistic spectrum symptoms under chronic social defeat stress in anxious male mice: effects of diazepam]. Psychopharmacol Biol Narcol. 2010;10(1-2):2624-2635. Epub 23 July, 2010. Russian. BACKGROUND. It is well known that psychoemotional disorders may be accompanied by decreased sociability in humans. It has been shown that repeated social defeat stress produced by 10 daily agonistic interactions led to development of the pronounced anxiety in male mice. The paper aimed to study the features of communicative behavior in anxious animals. METHODS. The sensory contact model was used to form high level of anxiety in male mice. The level of anxiety was measured in elevated plus-maze test. Communicative behavior was studied in the social interaction and partition tests as a behavioral reaction toward the other partner. RESULTS. It has been shown that communication toward familiar and unfamiliar partners and exploratory activity were dramatically decreased in anxious mice. Avoidance of approaching partner and demonstration of self-grooming were significantly increased in animals under repeated social defeats. Chronic diazepam treatment (0.5 mg/kg, i.p., 2 weeks) led to significant decrease of anxiety level and to improvement of communication. Diazepam completely has restored the level of sociability and exploratory activity and reduced avoidance behavior of approaching partner. Diazepam did not affect self-grooming behavior. CONCLUSIONS. Main factor which provokes impairment of communication in defeated male mice is the high level of anxiety. Results have demonstrated similarity between changes in social behaviors in anxious animals and symptoms of autistic spectrum disorders in humans. [in Russian with English Summary]. Date submitted: June 06, 2010; Accepted: July 22, 2010. Citation: Psychopharmacol Biol Narcol. 2010;10 (1-2):2624-2635
Psychopharmacology & biological narcology. 2010;10(1-2):2624-2635
pages 2624-2635 views

Repeated Aggression and Implications of Deprivation in Male Mice

Smagin D.A., Bondar' N.P., Kudryavtseva N.N., Smagin D.A., Bondar N.P., Kudryavtseva N.N.

Abstract

Smagin DA, Bondar NP, Kudryavtseva NN. [Repeated aggression and implications of deprivation in male mice]. Psychopharmacol Biol Narcol. 2010;10(1-2):2636-2648. Epub 06 November, 2010. Russian. BACKGROUND. Male mice with a long positive fighting history develop behavioral psychopathology, which includes abnormal aggression, pronounced anxiety, hyperactivity, stereotypic reactions, disturbances in social recognition etc. METHODS. Behavior of C57BL/6J male mice with 20 days experience of aggression was investigated before and after no-fight period (14 days) in elevated plus maze, open field, partition and agonistic interactions tests. RESULTS. It was shown that level of aggression was increased in 67 % of males and was decreased in 33 % of males after fighting deprivation. These two groups of animals differed initially in aggression levels before no-fight period: higher aggression level was in the males that decreased afterwards manifestation of aggression. However these males had no differences in many psychoemotional characteristics evaluated in elevated plus maze, open field and partition tests. CONCLUSION. Positive fighting experience affects subsequent agonistic behavior increasing aggressiveness in most part of male mice after fighting deprivation. It is supposed that brain opioidergic systems are involved in the effects of repeated aggression and deprivation effects. Date submitted: September 29, 2010; Accepted: November 06, 2010. Citation: Psychopharmacol Biol Narcol. 2010;10(1-2):2636-2648
Psychopharmacology & biological narcology. 2010;10(1-2):2636-2648
pages 2636-2648 views

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