Effects of Levetiracetam on the Content of Neurotransmitter Amino Acids in the Brain of Rats with the Audiogenic Epileptiform Siezures
- Autores: Malikova L.A.1, Fedotova I.B.1, Klodt P.M.1, Surina N.M.1, Poletaeva I.I.1, Kudrin V.S.1, Raevskiy K.S.1, Malikova LA2, Fedotova IB3, Klodt PM2, Surina NA3, Kudrin VS2, Poletaeva II3, Rayevsky KS2
-
Afiliações:
- Zakusov Institute of Pharmacology Russian Academy of Medical Sciences
- Lomonosov State University
- Edição: Volume 8, Nº 3-4 (2008)
- Páginas: 2448-2452
- Seção: Articles
- URL: https://journals.eco-vector.com/1606-8181/article/view/322002
- DOI: https://doi.org/10.17816/phbn322002
- ID: 322002
Citar
Texto integral
Resumo
Sobre autores
Lyudmila Malikova
Email: ludmal2006@yandex.ru
Irina Fedotova
Petr Klodt
Natal'ya Surina
Inga Poletaeva
Vladimir Kudrin
Kirill Raevskiy
L Malikova
Zakusov Institute of Pharmacology Russian Academy of Medical SciencesZakusov Institute of Pharmacology Russian Academy of Medical Sciences
I Fedotova
Lomonosov State University; Lomonosov State University
P Klodt
Zakusov Institute of Pharmacology Russian Academy of Medical SciencesZakusov Institute of Pharmacology Russian Academy of Medical Sciences
N Surina
Lomonosov State University; Lomonosov State University
V Kudrin
Zakusov Institute of Pharmacology Russian Academy of Medical SciencesZakusov Institute of Pharmacology Russian Academy of Medical Sciences
I Poletaeva
Lomonosov State University; Lomonosov State University
K Rayevsky
Zakusov Institute of Pharmacology Russian Academy of Medical SciencesZakusov Institute of Pharmacology Russian Academy of Medical Sciences
Bibliografia
- Бадалян О.Л., Бурд С.Г., Савенков А.А. и др. Оптимизация фармакотерапии эпилепсии. Возможности применения габапентина. // Неврология. 2006. Т. 14, № 9. С. 710-713.
- Калинин В.В. Препарат леветирацетам (кеппра) в эпилептологии. // Ж. неврол. и психиат. 2007. Т. 107, № 3. С. 74-77.
- Карлов В.А., Власов П.Н. Эффективность кеппры в составе комплексной терапии при фармакорезистентной эпилепсии у взрослых. // Ж. неврол. и психиат. 2005. № 7. С. 40-44.
- Маликова Л.А., Федотова И.Б., Полетаева И.И., Раевский К.С. Противосудорожное действие леветирацетама при аудиогенных эпилептиформных припадках у крыс Крушинского-Молодкиной. // Эксперим. и клин. фармакол. 2007. Т. 70, № 6. С. 3-5.
- Раевский К.С., Маликова Л.А., Калинин В.А. Нейрональные и нейрохимические механизмы действия нового антиэпилептического препарата леветирацетама. // Эксперим. и клин. фармакол. 2007. Т. 70, № 2. С. 70-74.
- Семиохина А.Ф., Федотова И.Б., Полетаева И.И. Крысы линии Крушинского-Молодкиной: исследования аудиогенной эпилепсии, сосудистой патологии и поведения. // Ж. высш. нерв. деят. 2006. Т. 56, № 3. С. 298-316.
- Энциклопедия лекарств. Ежегодный сборник. М.: «РЛС-2007», 2006.
- Hanon E., Klitgaard H. Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia. // Seizure. 2001. Vol. 10, N 4. P. 287-293.
- De Smedt T., Raedt R., Vonck K., Boon P. Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. // CNS Drug Rev. 2007. Vol. 13, N 1. P. 43-56.
- De Smedt T., Raedt R., Vonck K., Boon P. Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug. // CNS Drug Rev. 2007. Vol. 13, N 1. P. 57-78.
- Dedeurwaerdere S., Vonck K., De Herdt V., et al. Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy. // Acta Neurol. Belg. 2006. Vol. 106, N 2. P. 91-97.
- Dufour F, Nalecz K.A., Nalecz M.J., Nehlig A. Modulation of absence seizures by branched-chain amino acids: correlation with brain amino acid concentrations. // Neurosci. Res. 2001. Vol. 40, N 3. P. 255-263.
- Lynch B.A., Lambeng N., Nocka, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. // Proc. Natl. Acad. Sci. USA. 2004. Vol. 101, N 26. P. 9861-9866.
- Klitgaard H., Matagne A., Gobert J., Wulfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. // Eur.J. Pharmacol. 1998. Vol. 353 (2-3). P. 191-206.
- Klitgaard H. Levetiracetam: the preclinical profile of a new class of antiepileptic drugs? // Epilepsia. 2001. Vol. 42, N 4. P. 13-18
- Meurs A., Clinckers R., Ebinger G., et al. Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. // Epilepsy Res. 2008. Vol. 78, N 1. P. 50-59.
- Pearson S.J., et al. Electrochemical detection of human brain transmitter amino acids by high-performance liquid chromatography of stable o-phtalaldehyde-sulphite derivatives. // J. Neuronal. Transm. 1991. Vol. 86. P. 151-157.
- Popova L.D. The influence of kynurenic acid on the content of excitatory and inhibitory mediators in rats with different levels of seizure susceptibility. // Ukr. Biokhim Zh. 2006. Vol. 78, N 5. P. 120-126.
- Sills G.J., Leach J.P., Fraser C.M., et al. Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. // Eur.J. Pharmacol. 1997. Vol. 325, N 1. P. 35- 40.
Arquivos suplementares
![](/img/style/loading.gif)