Effects of Single and Chronic Naltrexone Treatment on Agonistic Behavior of Male Mice with Repeated Experience of Aggression



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Bondar NP, Smagin DA, Kudryavtseva NN. [Effects of single and chronic naltrexone treatment on agonistic behavior of male mice with repeated experience of aggression]. Psychopharmacol Biol Narcol. 2011; 11(1-2).
Epub 14 Oktober 2011. Russian.


BACKGROUND. Experimental studies have shown that the effect of clinical drugs (diazepam, buspirone, haloperidol, etc.) on aggressiveness of male mice with repeated experience of aggression accompanied by victories depended on the duration of aggression experience. The aim of this study was to examine in detail in experienced winners antiaggressive effects of blocker of opioid receptors naltrexone, which effectively reduces the aggression in males without a consecutive experience of aggression.
METHODS. Effects of naltrexone (single injection, 1 and 2 mg/kg, s.c.) were examined in male mice after 3, 10 and 20 days of intermale interactions, as well as in males with 20-days aggressive experience after the cessation of agonistic interactions (deprivation). In addition, naltrexone (2 mg/kg, s.c) was administered chronically from the 7th day for 2 weeks on ongoing agonistic interactions. 20-days experienced winners were also injected chronically during 2 weeks deprivation.
RESULTS. Single injection of naltrexone effectively reduced the aggression in male mice with 3 and 10 days aggressive experience, but had no effect on male mice with 20 days experience. Naltrexone produced antiaggressive effect in males after period of deprivation. Chronic treatment with naltrexone on the background of aggressive interactions had no significant protective effect on most parameters, evaluating agonistic behavior, increasing aggressive motivation and total time of hostile behavior toward a partner. Chronic naltrexone treatment during deprivation did not prevent post-deprivation increase of aggression and even somewhat increased indirect aggression (diggings of partner's sawdust).
CONCLUSION. Single treatment by naltrexone decreases aggression in male mice with small experience of aggression and is ineffective in male mice with prolonged aggressive experience. Period of deprivation restors sensitivity to antiaggressive effects of naltrexone. Chronic blockade of opioid receptors that mediates positive reinforcement has no significant effect on aggression in experienced winners.
Date submitted: July 24, 2011; Accepted: Oktober 13, 2011.


Citation: Psychopharmacol Biol Narcol. 2011;11 (1-2):2688-2700

Sobre autores

Natal'ya Bondar'

Email: n.n.kudryavtseva@gmail.com

Dmitriy Smagin

Email: n.n.kudryavtseva@gmail.com

Nataliya Kudryavtseva

Email: n.n.kudryavtseva@gmail.com

N Bondar

Institute of Cytology and Genetics SD RAS

; Institute of Cytology and Genetics SD RAS

D Smagin

Institute of Cytology and Genetics SD RAS

; Institute of Cytology and Genetics SD RAS

N Kudryavtseva

Institute of Cytology and Genetics SD RAS

Email: n.n.kudryavtseva@gmail.com
; Institute of Cytology and Genetics SD RAS

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