Effects of Single and Chronic Naltrexone Treatment on Agonistic Behavior of Male Mice with Repeated Experience of Aggression
- 作者: Bondar' N.P.1, Smagin D.A.1, Kudryavtseva N.N.1, Bondar NP2, Smagin DA2, Kudryavtseva NN2
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隶属关系:
- Institute of Cytology and Genetics SD RAS
- 期: 卷 11, 编号 1-2 (2011)
- 页面: 2688-2700
- 栏目: Articles
- URL: https://journals.eco-vector.com/1606-8181/article/view/322023
- DOI: https://doi.org/10.17816/phbn322023
- ID: 322023
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Epub 14 Oktober 2011. Russian.
BACKGROUND. Experimental studies have shown that the effect of clinical drugs (diazepam, buspirone, haloperidol, etc.) on aggressiveness of male mice with repeated experience of aggression accompanied by victories depended on the duration of aggression experience. The aim of this study was to examine in detail in experienced winners antiaggressive effects of blocker of opioid receptors naltrexone, which effectively reduces the aggression in males without a consecutive experience of aggression.
METHODS. Effects of naltrexone (single injection, 1 and 2 mg/kg, s.c.) were examined in male mice after 3, 10 and 20 days of intermale interactions, as well as in males with 20-days aggressive experience after the cessation of agonistic interactions (deprivation). In addition, naltrexone (2 mg/kg, s.c) was administered chronically from the 7th day for 2 weeks on ongoing agonistic interactions. 20-days experienced winners were also injected chronically during 2 weeks deprivation.
RESULTS. Single injection of naltrexone effectively reduced the aggression in male mice with 3 and 10 days aggressive experience, but had no effect on male mice with 20 days experience. Naltrexone produced antiaggressive effect in males after period of deprivation. Chronic treatment with naltrexone on the background of aggressive interactions had no significant protective effect on most parameters, evaluating agonistic behavior, increasing aggressive motivation and total time of hostile behavior toward a partner. Chronic naltrexone treatment during deprivation did not prevent post-deprivation increase of aggression and even somewhat increased indirect aggression (diggings of partner's sawdust).
CONCLUSION. Single treatment by naltrexone decreases aggression in male mice with small experience of aggression and is ineffective in male mice with prolonged aggressive experience. Period of deprivation restors sensitivity to antiaggressive effects of naltrexone. Chronic blockade of opioid receptors that mediates positive reinforcement has no significant effect on aggression in experienced winners.
Date submitted: July 24, 2011; Accepted: Oktober 13, 2011.
Citation: Psychopharmacol Biol Narcol. 2011;11 (1-2):2688-2700
作者简介
Natal'ya Bondar'
Email: n.n.kudryavtseva@gmail.com
Dmitriy Smagin
Email: n.n.kudryavtseva@gmail.com
Nataliya Kudryavtseva
Email: n.n.kudryavtseva@gmail.com
N Bondar
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
D Smagin
Institute of Cytology and Genetics SD RAS; Institute of Cytology and Genetics SD RAS
N Kudryavtseva
Institute of Cytology and Genetics SD RAS
Email: n.n.kudryavtseva@gmail.com
; Institute of Cytology and Genetics SD RAS
参考
- DSM-IV-TR. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. American Psychiatric Assosiation: Washington DC, 2000. 955 p.
- Haller J., Kruk M.R. Normal and abnormal aggression: human disorders and novel laboratory models. Neurosci Biobehav Rev. 2006; 30(3): 292-303.
- Pabis D.J., Stanislav S.W. Pharmacotherapy of aggressive behavior. Ann Pharmacother. 1996; 30(3): 278-287.
- Kudryavtseva N.N. Psychopathology of repeated aggression: a neurobiological aspect. In: Morgan J.P. (ed). Perspectives on the Psychology of Aggression. NOVA Science Publishers, Inc., 2006. P 35-64.
- Kudryavtseva N.N., Lipina T.V., Koryakina L.A. Effects of haloperidol on communicative and aggressive behavior in male mice with different experiences of aggression. Pharmacol Biochem Behav. 1999; 63(2): 229-236.
- Бондарь Н.П., Кудрявцева Н.Н. Влияние антагониста D1-рецепторов SCH 23390 на индивидуальное и агрессивное поведение самцов мышей с разным опытом агрессии. Росс физиол журн им. И.М. Сеченова. 2003; 89(8): 992-1000.
- Бондарь Н.П., Кудрявцева Н.Н. Влияние буспирона на агрессивное и тревожное поведение самцов мышей с различным опытом агрессии. Эксперим клин фармакол. 2003; 66(4): 12-16.
- Смагин Д.А., Бондарь Н.П., Кудрявцева Н.Н. Влияние вальпроата натрия на агрессивное поведение самцов мышей с разным опытом агрессии. Эксперим клин фармакол. 2010; 73(1): 10-15.
- Кудрявцева Н.Н., Бондарь Н.П. Анксиолитический и анксиогенный эффекты диазепама у самцов мышей с различным опытом агрессии. Бюлл эксперим биол мед. 2002; 133(4): 429-433.
- Кудрявцева Н.Н., Долгов В.В., Августинович Д.Ф., Алексеенко О.В., Липина Т.В., Корякина Л.А. Модифицирующее влияние повторного опыта агонистических взаимодействий на эффекты налтрексона у самцов мышей. Росс физиол журн им. И.М. Сеченова. 2001; 87(2): 227-238.
- Липина Т.В., Августинович Д.Ф., Корякина Л.А., Алексеенко О.В., Кудрявцева Н.Н. Различия в эффектах налтрексона на коммуникативное и агрессивное поведение у особей с различным опытом социальных побед. Эксперим клин фармакол. 1998; 61(3): 13-18.
- Kudryavtseva N.N., Gerrits M.A., Avgustinovich D.F., Tenditnik M.V., Van Ree J.M. Modulation of anxiety-related behaviors by mu- and kappa-opioid receptor agonists depends on the social status of mice. Peptides. 2004; 25(8): 1355-1363.
- Бондарь Н.П., Смагин Д.А., Григорьева А.Е., Галямина А.Г., Кудрявцева Н.Н. Влияние блокады опиоидных рецепторов на поведение самцов мышей с разным опытом агрессии: Материалы ХХ Съезда Физиологического Общества им. И.П. Павлова. 2010, Калуга, Россия. С. 79.
- Cooper S.J. Interaction between endogenous opioids and dopamine: Implications for reward and aversion. In: Willner P., Scheel-Kruger J. (eds). The mesolimbic dopamine system: from motivation to action. John Wiley Sons Ltd: London, 1991. P. 331-366.
- Le Merrer J., Becker J.A., Befort K., Kieffer B.L. Reward processing by the opioid system in the brain. Physiol Rev. 2009; 89(4): 1379-1412.
- Miczek K.A., Tornatzky W. Ethopharmacology of aggression: impact on autonomic and mesocorticolimbic activity. Ann NY Acad Sci. 1996; 794: 60-77.
- Miczek K.A., Weerts E., Haney M., Tidey J. Neurobiological mechanisms controlling aggression: preclinical developments for pharmacotherapeutic interventions. Neurosci Biobehav Rev. 1994; 18(1): 97-110.
- Fish E.W., De Bold J.F., Miczek K.A. Aggressive behavior as a reinforcer in mice: activation by allopregnanolone. Psychopharmacology (Berl). 2002; 163(3-4): 459-466.
- Hsu Y., Earley R.L., Wolf L.L. Modulation of aggressive behaviour by fighting experience: mechanisms and contest outcomes. Biol Rev. 2006; 81(1): 33-74.
- Scott J.P. Agonistic behavior of mice and rats: a review. Am Zool. 1966; 6(4): 683-701.
- Baron R.A., Richardson D. Human aggression. Plenum Press: New York, 1994. 351 p.
- Пошивалов В.П. Экспериментальная психофармакология агрессивного поведения. Л.: Наука, 1986. 176 с.
- Benton D. Mu and kappa opiate receptor involvement in agonistic behaviour in mice. Pharmacol Biochem Behav. 1985; 23(5): 871-876.
- Lynch W.C., Libby L., Johnson H.F. Naloxone inhibits intermale aggression in isolated mice. Psychopharmacology (Berl). 1983; 79(4): 370-371.
- Olivier B., Van Dalen H. Social behavior in rats and mice: an ethologically based model for differentiating psychoactive drugs. Aggressive Behavior. 1982; 8: 163-168.
- Puglisi-Allegra S., Oliverio A., Mandel P. Effects of opiate antagonists on social and aggressive behavior of isolated mice. Pharmacol Biochem Behav. 1982; 17(4): 691-694.
- Rodgers R.J., Hendrie C.A. Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: effects of naloxone on nociception and behaviour. Physiol Behav. 1983; 30(5): 775-780.
- Benton D., Brain B.F. The role of opioid mechanisms in social interaction and attachment. In: Rodgers R.J., Cooper S.J. (eds). Endorphins, opiates and behaviuoral processes. NY: Wiley & Sons Ltd, 1988. P. 217-235.
- Kudryavtseva N.N., Avgustinovich D.F., Bondar N.P., Tenditnik M.V., Kovalenko I.L. An experimental approach for the study of psychotropic drug effects under simulated clinical conditions. Curr Drug Metab. 2008; 9(4): 352-360.
- Смагин Д.А., Бондарь Н.П., Кудрявцева Н.Н. Повторный опыт агрессии и последствия депривации у самцов мышей. Психофармакол биол наркол. 2010; 10(1-2): 2636-2648.
- Kudryavtseva N.N. The sensory contact model for the study of aggressive and submissive behaviors in male mice. Aggressive Behavior. 1991; 17(5): 285-291.
- Kudryavtseva N.N. Use of the «partition» test in behavioral and pharmacological experiments. Neurosci Behav Physiol. 2003; 33(5): 461-471.
- Kudryavtseva N.N., Bondar N.P., Alekseyenko O.V. Behavioral correlates of learned aggression in male mice. Aggress Behav. 2000; 26(5): 386-400.
- Goloshchapov A.V., Filipenko M.L., Bondar N.P., Kudryavtseva N.N., Van Ree J.M. Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression. Brain Res Mol Brain Res. 2005; 135(1-2): 290-292.
- Kudryavtseva N.N., Amstislavskaya T.G., Kucheryavy S. Effects of repeated aggressive encounters on approach to a female and plasma testosterone in male mice. Horm Behav. 2004; 45(2): 103-107.
- Bondar N.P., Kovalenko I.L., Avgustinovich D.F., Smagin D.A., Kudryavtseva N.N. Anhedonia in the shadow of chronic social defeat stress, or when the experimental context matters. Open Behav Sci. J. 2009; 3: 17-27.
- Kudryavtseva N.N., Smagin D.A., Bondar N.P. Modeling fighting deprivation effect in mouse repeated aggression paradigm. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35: 1472-1478.
- Кудрявцева Н.Н., Долгов В.В., Бондарь Н.П., Августинович Д.Ф. Влияние селективного агониста µ-опиоидных рецепторов DAGO на враждебное и тревожное поведение самцов мышей с разным опытом агрессии. Журн высш нервн деят им. И.П. Павлова. 2003; 53(1): 81-87.
- Kudryavtseva N.N. Straub tail, the deprivation effect and addiction to aggression. In: O'Neal PW (ed). Motivation of Health Behavior. NOVA Science Publishers Inc., 2007. P. 97-110.
- Van Ree J.M., Gerrits M.A., Vanderschuren L.J. Opioids, reward and addiction: An encounter of biology, psychology, and medicine. Pharmacol Rev. 1999; 51(2): 341-396.
- de Boer S.F., Koolhaas J.M. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. Eur J Pharmacol. 2005; 526(1-3): 125-139.
- Miczek K.A., Faccidomo S.P., Fish E.W., De Bold J.F. Neurochemistry and molecular neurobiology of aggressive behavior In: Lajtha A., Blaustein J.D. (eds). Handbook of Neurochemistry and Molecular Neurobiology: Behavioral neurochemistry, neuroendocrinology and molecular neurobiology. Berlin-Heidelberg: Springer-Verlag, 2007. P. 285-336.
- Вальдман А.В., Пошивалов В.П. Фармакологическая регуляция внутривидового поведения. Л.: Медицина, 1984. 208 с.
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