The role of neurotrophic factors of placenta in development of the fetus brain in hyperhomocysteinemia
- Authors: Arutjunyan A.V1, Milyutina Y.P1, Zalozniaia I.V1, Shcherbitskaia A.D2, Kerkeshko G.O1
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Affiliations:
- D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology
- I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences
- Issue: Vol 17, No 3 (2019)
- Pages: 3-7
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113084
- DOI: https://doi.org/10.29296/24999490-2019-03-01
- ID: 113084
Cite item
Abstract
This review article focuses on modern ideas about the role of neurotrophic factors (BDNF, NGF, NRG1, etc.) in the formation of the placenta and their impact on the development of the nervous system in early ontogenesis. Data on the common effect of neurotrophic factors with vascular endothelial growth factor and metalloproteinases on angiogenesis in the placenta and fetal brain are presented. Issues related to the effect of pro-inflammatory cytokines and oxidative stress on the neurotrophin expression in the placenta, as well as on the fetal brain development are discussed. Thepro-apoptotic effect of L-homocysteine on trophoblast cells is associated with oxidative stress, while neurotrophins expressed in the placenta display an anti-apoptotic effect. The oxidative stress is shown to be crucial for long-term impairments in the development of the nervous system and cognitive function in the offspring in hyperhomocysteinemia. This disorder also causes an increase in DYRK1A protein brain level, accompanied by neurodegeneration, the decline in BDNF protein brain level in the mature brain, and impaired brain development in fetuses, leading to cognitive impairment in the offspring. The molecular mechanisms of the effect of prenatal hyperhomocysteinemia on the level of neurotrophins and their precursors in the placenta and fetal brain do not seem completely clear and need further study.
Full Text
About the authors
A. V Arutjunyan
D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology
Email: alexarutiunjan@gmail.com
Yu. P Milyutina
D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology
I. V Zalozniaia
D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology
A. D Shcherbitskaia
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences
G. O Kerkeshko
D.O. Ott Institute of Obstetrics, Gynecology, and Reproductology
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