Molecular mechanisms of possible use of metabolites for prevention, therapy and rehabilitation of patients with COVID-19
- Authors: Mashkovtseva E.V.1, Nartsissov Y.R.1
-
Affiliations:
- Institute of Cytochemistry and Molecular Pharmacology, Russian Federation
- Issue: Vol 19, No 6 (2021)
- Pages: 11-18
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113525
- DOI: https://doi.org/10.29296/24999490-2021-06-02
- ID: 113525
Cite item
Abstract
The purpose of this review was to describe information about the etiology and pathogenesis of the main manifestations in patients with coronavirus infection COVID-19 and the molecular mechanisms of the possible use of metabolite drugs. Material and methods. The full-text search has been carried out in the Medline (Pubmed) and Scopus databases over the past 15 years. Results. Based on the results of the analysis the mechanisms of microcirculation disorders, possible ways of the virus penetration into the central nervous system and its effect on brain cells are described in detail. Neuronal damage and disruption of their normal functioning can lead to long-term consequences of infection. The use of metabolites to correct the cell state can soflty reduce inflammation through a range of molecular mechanisms. Conclusions. The proven cytoprotective and immunomodulatory effect of glycine determines its possible use in the therapy of COVID-19. The use of antioxidants such as glutathione is pathogenetically justified for the correction of endothelial dysfunction and neuronal hypoxia.
Full Text
About the authors
Elena Valeryevna Mashkovtseva
Institute of Cytochemistry and Molecular Pharmacology, Russian Federation
Email: elenamash@gmail.com
Director
Yaroslav Ryurikovich Nartsissov
Institute of Cytochemistry and Molecular Pharmacology, Russian Federation
Email: yarosl@biotic.dol.ru
Head of Department of mathematical modeling and statistics
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