Saliva concentration of sirtuins: perspectives of application for coronary heart disease diagnostics and aging rate


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Abstract

The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «norm») and 68 CHD patients of middle age and elderly age. Sirt1, Sirt3, Sirt4, Sirt5, Sirt6, Sirt7concentrations were verified in saliva by enzymoimmunoassay. Results. Sirt1, Sirt6, Sirt7 concentrations in saliva in elderly patients from the group «norm» were 1.5-1.6 times lower in comparison with this value in middle-aged patients. Sirt1, Sirt 3, Sirt6, Sirt7 concentrations in saliva in middle-aged and elderly CHD patients were 1.4-4.2 times lower in comparison with the same values in patients of this age in group «norm». Sirt1, Sirt6, Sirt7 concentrations in saliva in elderly CHD patients were 1.5-2.1 times lower in comparison with these values in middle age CHD patients. Conclusions. The Sirt1, Sirt6, Sirt7 saliva study in healthy middle and old people can be used in a comprehensive assessment of biological age . The estimation of Sirt1, Sirt3, Sirt6, Sirt7 concentration in saliva in middle age and elderly patients may be the perspective predictive method of CHD.

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About the authors

Natalia Sergeevna Linkova

Belgorod National Research University; Academy of postgraduate education under FSBUFSCC of FMBA of Russia; Saint Petersburg Institute of Bioregulation and Gerontology

Email: miayy@yandex.ru
doctor of biological sciences, associate professor, the head of the laboratory of Molecular mechanisms of aging of Biogerontology department; geriatrics and anti-age medicine; senior researcher of the laboratory “Problems of aging”

Anastasiia Eduardovna Pychalskaya

Saint Petersburg Institute of Bioregulation and Gerontology

Email: nastyapuh96@mail.ru
the scientific research of the laboratory of molecular mechanisms of aging

Andrey Nikolaevich Il’nitskii

Belgorod National Research University; Academy of postgraduate education under FSBUFSCC of FMBA of Russia

Email: a-ilnitski@yandex.ru
the head of the Department of therapy, geriatrics and antiaging medicine of Academy of postgraduate education

Uliana Alexandrovna Novak-Bobarikina

Saint-Petersburg State University

Email: ulyana.boba0304@mail.ru
postgraduate student of the Pathology Department

Ol’ga Alexandrovna Osipova

Belgorod National Research University

Email: osipova@bsu.edu.ru
associate Director of the Center of Additional Medical and Pharmaceutical Education, Accreditation and Certification of Medical Institute and Professor of Therapy Department

Ol’ga Anatol’evna Rozhdestvenskaya

Belgorod National Research University

Email: longtermcare.fmba@gmail.com
the docent of the Department of therapy, geriatrics and antiaging medicine

Kirill Lenarovich Kozlov

Saint Petersburg Institute of Bioregulation and Gerontology

Email: kozlov_kl@mail.ru
the head of the Department of Clinical Gerontology and Geriatry

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