Ihe role of physical activity in the processes of neurogenesis in the hippocampus
- Authors: Vinogradova A.V.1, Smirnova P.A.1, Yakovchuk Z.Y.1, Tuchina O.P.1
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Affiliations:
- Immanuel Kant Baltic Federal University
- Issue: Vol 20, No 4 (2022)
- Pages: 22-27
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113780
- DOI: https://doi.org/10.29296/24999490-2022-04-04
- ID: 113780
Cite item
Abstract
The purpose of this review was to determine the role of physical activity as an integral component of environmental enrichment in the processes of neurogenesis in the rodent hippocampus. Material and methods. The full-text search has been carried out in the Medline (Pubmed) and Scopus databases over the past 15 years. Results. Physical activity affects neuronal precursors of the dentate gyrus of the hippocampus, probably acting through several molecular mechanisms: 1) an increase in the systemic concentration of glycolysis products (primarily lactate) promotes increased blood supply to the dentate gyrus and angiogenesis; 2) muscle-released myokines stimulate the expression of neurotrophic factors such as brain-derived neurotrophic factor BDNF; 3) a decrease in the number of adipocytes and a decrease in the concentration of leptin with regular training changes leukopoiesis, inhibiting the proliferation of potentially pro-inflammatory leukocytes; 4) stimulation of the vagus nerve contributes to the regulation of systemic inflammation and depolarization of granule cells, which probably stimulates the differentiation of neuronal progenitors. Conclusion. Physical activity, regardless of other components of the enriched environment, stimulates the proliferation and survival of neuronal precursors of the dentate gyrus of the hippocampus.
Full Text
About the authors
Anna Vyacheslavovna Vinogradova
Immanuel Kant Baltic Federal University
Email: anna.vinogradova.97@yandex.ru
PhD student High School of Life Sciences
Russian Federation,Polina Andreevna Smirnova
Immanuel Kant Baltic Federal University
Email: sp.polinasmirnova@gmail.com
master student High School of Life Sciences
Russian Federation,Zlata Yuryevna Yakovchuk
Immanuel Kant Baltic Federal University
Email: zlata.yakovchuk.ur@gmail.com
master student High School of Life Sciences
Russian Federation,Oksana Pavlovna Tuchina
Immanuel Kant Baltic Federal University
Author for correspondence.
Email: otuchina@kantiana.ru
head of laboratory for Synthetic biology, High School of Life Sciences
Russian Federation,References
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