Eosinophils are predictors of susceptibility to thrombosis and severe course of Covid-19 in various types of therapy

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Abstract

The creation by COVID-19 of methods for prophylactic of these complications as blood hypercoagulation, leading to thrombosis and polyorganic insufficiency, is an urgent task of modern biology and medicine. The aim of the study was to develop the simple methods, by which it is possible make prognosis of the changes in the blood coagulation peculiarities by this illness and by different methods of treatment. Methods. The patients with severe COVID-19 were separated to 3 groups. 1- control (basic scheme of treatment), 2- (basic scheme of treatment and Tocilizumab), 3- (basic scheme of treatment and Thymalin). Evaluation of the dynamic of eosinophil and thrombocytes number was performed using hemoanalyzer PENTRA-80 Horiba ABX Diagnostics. The detection of basic index of coagulogramm was performed using the coagulometer Sysmex. The connection of eosinophil number to the changes of the basic rate of coagulogramm. Results. It was established, that eosinophils are the are the predictors of change both of coagulation and of thromb formation in the blood. The positive effect of Thymalin, as compared to Tocilizumab, on the blood coagulation system by sever COVID-19 is established. Conclusion. It is established that by immunocorector using by sever COVID-19 Thymalin is mostly effective for treatment and prophylactic of complications.

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About the authors

Boris Ilich Kuznik

Chita State Medical Academy

Email: bi_kuznik@mail.ru

chief of cathedra of normal physiology

Russian Federation,

Yurii Nikolaevich Smolyakov

Chita State Medical Academy

Email: smolyakov@rambler.ru

chief of cathedra of medical physic and informatics

Russian Federation,

Konstantin Gennadyevich Shapovalov

Chita State Medical Academy

Email: shkg26@mail.ru

chief of cathedra of anestesiology, reanimation and intensive therapy

Russian Federation,

Ludmila Sergeevna Kazantseva

GUZRegional Clinical Infectious Diseases Hospital

Email: mila-kaz.antseva93@mail.ru

chief of hospital unit of reanimation and intensive therapy

Russian Federation,

Natalia Iosifovna Chalisova

ANO SIC «St. Petersburg Institute of Bioregulation and Gerontology»; Pavlov Institute of Physiology of the Russian Academy of Sciences

Author for correspondence.
Email: ni_chalisova@mail.ru

leading researcher; Senior researcher of the laboratory of Oncogerontology of Biogerontology department

Russian Federation,

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Supplementary files

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2. Fig. 1. ROC evaluation of coagulogramm and eosinophils by using of treatment traditional schema

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3. Fig. 2. ROC evaluation of coagulogramm and eosinophils by using of Tocilizumab

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4. Fig. 3. ROC evaluation of coagulogramm and eosinophils by using of Tymalin

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