Effect of dipeptides on cellular growth in organotypic culture of tissues from young and old rats
- Authors: Chalisova N.I.1,2, Ryzhak G.A.1, Khavinson V.K.1,2
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Affiliations:
- Saint Petersburg Institute of Bioregulation and Gerontology
- Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 20, No 4 (2022)
- Pages: 56-59
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113788
- DOI: https://doi.org/10.29296/24999490-2022-04-09
- ID: 113788
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Abstract
Dipeptides are physiological products of protein degradation and informational molecules. Asp-Pro, Asp-Ala, Glu-Ala peptides have geroprotective, reparative properties. The aim of the work is to evaluate the effect of the Asp-Pro, Asp-Ala и Glu-Ala peptides on the development of organotypic tissue culture (bronchi, vessels, brain subcortical structures)in young and old rats. Material and methods. Tissues for organotypic cultivation of bronchi, vessels, brain subcortical structures were obtained from young (2-3 months) and old (18-20 months) Wistar rats. Results. Asp-Pro peptide stimulated cell growth in bronchi tissues of young and old animals. Asp-Ala peptide activated cell proliferation in vessels tissues of young and old rats. Glu-Ala peptide had a stimulating effect on the brain subcortical structures tissue of young and old rats. Conclusion. Asp-Pro, Asp-Ala, Glu-Ala peptides have effects on corresponding tissues obtained from animals of different ages. This indicates the possibility of base formation for working of preparations, including the geroprotective, perfecting the functional activity of bronchi, vessels, brain subcortical structures.
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About the authors
Natalia Iosifovna Chalisova
Saint Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology, Russian Academy of Sciences
Email: ni_chalisova@mail.ru
leading researcher; Senior researcher of the laboratory of Oncogerontology of Biogerontology department
Russian Federation,Galina Anatol’evna Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Email: galina@gerontology.ru
associate Director in scientific investigation
Russian Federation,Vladimir Khatzkelevich Khavinson
Saint Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: khavinson@gerontology.ru
Director
Russian Federation,References
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