Fibroblast growth factors and their effect on cognitive functions and the course of central nervous system degenerative diseases

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Abstract

Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man factor FGFd, including 22 structurally connected polypeptides, is necessary for the neuroprotection by the CNS degenerative pathology is presented playing a great role in neuroprotection, cognitive functions state. The factors FGF1, FGF2, FGF8. FGF17, FGF18, FGF20. FGF21 and their receptor (RFGF) in natural conditions plays a great role in nerve system structures preservation, in formation and preservation of long-term memory and other cognitive functions. Methods. Inroduction in old rat experiments the plasma or cerebrospinal fluid of young rats and also of recombinant FGFs. Results. The cerebrospinal fluid of young rats increased the proliferation and differentiation of oligodendrocyte cell-precursors in the hippocampus of old animals and this lead to great closing of cognitive disfunctions and reformed the leaning and memory. Conclusion. FGFs investigation create the basis for the preparation elaboration, which restore cognitive functions by aging and CNS degenerative pathology (Alzheimer and Parkinson diseases, stroke).

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About the authors

Boris Ilich Kuznik

Chita State Medical Academy, Russian Federation

Author for correspondence.
Email: bi_kuznik@mail.ru
Honorable chief of cathedra of normal physiology; Doctor of medical sciences, professor. 672000, Trans-Baikal Territory, Chita, st. Gorky 39a

Ecaterina Sergeevna Guseva

Innovation Clinic Academy of Health

Email: guseva81@gmail.com
director assistance of clinic-expert and organization-methodic work; Candidate of medical sciences. Russian Federation, 672000, Chita, st. Kokhanskogo 13

Sergei Olegovich Davidov

Innovation Clinic Academy of Health

Email: davydov-so@mail.ru
chief; Doctor of medical sciences Russian Federation, 672000, Chita, st. Kokhanskogo 13

Natalia Iosifovna Chalisova

«St. Petersburg Institute of Bioregulation and Gerontology»; Institute of Physiology I.P. Pavlov Academy of Sciences

Email: ni_chalisova@mail.ru
leading researcher of Pavlov Institute of Physiology RAS. Senior researcher of the laboratory of Oncogerontology of Biogerontology department; Doctor of biologic sciences, professor. Russian Federation, 197110, St. Petersburg, Dynamo Ave., 3; Russian Federation, 199034, St. Petersburg, nab. Makarova, d. 6

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