Signaling molecules of tumor transformation in tuberculosis
- Authors: Krylova Y.S.1,2, Kudriashov G.G.1, Nefedov A.O.1, Dokhov M.A.1,3, Zakharchenko A.O.4, Yablonskii P.K.1,4
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Affiliations:
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- Pavlov First Saint Petersburg State Medical University
- St. Petersburg State Pediatric Medical University
- Saint-Petersburg University
- Issue: Vol 20, No 6 (2022)
- Pages: 12-15
- Section: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/321277
- DOI: https://doi.org/10.29296/24999490-2022-06-02
- ID: 321277
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Abstract
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the disease.
The aim of the study was to determine the current state of the issue and characterize the molecular markers of tumor transformation in tuberculosis.
Material and methods: analysis and systematization of scientific literature over the past 10 years was performed in the PubMed, Scopus and Google Scholar databases.
Results: particular attention in the review is given to the factors contributing to tumor transformation in tuberculosis. Both direct effects of Mycobacterium tuberculosis on proliferation and immune response, and indirect mechanisms of action on cells involved in inflammation processes are considered. The choice of signaling molecules to optimize the personalized diagnosis of tumor transformation in tuberculosis is substantiated.
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About the authors
Yulia S. Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: info@spbniif.ru
ORCID iD: 0000-0002-8698-7904
Senior Researcher, Center for Molecular Biomedicine. PhD.
Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Street L’va Tolstogo, 6–8, Saint-Petersburg, 197022Grigorii G. Kudriashov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: dr.kudriashov.gg@yandex.com
ORCID iD: 0000-0002-2810-8852
Senior researcher, thoracic surgeon
Ligovskij avenue, 2–4, Saint-Petersburg, 191036Andrey O. Nefedov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: herurg78@mail.ru
ORCID iD: 0000-0001-6228-182X
Senior Researcher, Head of the Department of Thoracic Oncology
Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036Mikhail A. Dokhov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; St. Petersburg State Pediatric Medical University
Email: info@spbniif.ru
ORCID iD: 0000-0002-7834-5522
Senior Researcher of the Center for Molecular Biomedicine
Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Litovskaya street, 2, Saint-Petersburg, 194100Aleksandra O. Zakharchenko
Saint-Petersburg University
Email: alz121@mail.ru
ORCID iD: 0000-0002-5398-0167
student of the Medical Faculty
Russian Federation, Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034Piotr K. Yablonskii
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg University
Email: info@spbniif.ru
ORCID iD: 0000-0003-4385-9643
director. MD, PhD, professor
Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034References
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