Biomarkers of endothelial damage and their role in predicting the development of sepsis and septic shock

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Abstract

Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as the structural basis of the circulatory system, is primarily exposed to pathogenetic factors, performing a protective function.

The purpose of this review was to summarize the results of assessing the diagnostic and prognostic effectiveness of molecular markers of endothelial damage in the development of inflammation, sepsis and septic shock.

Material and methods. The literature search was conducted using the databases PubMed/Medline, Elsevier.com., ResearchGate, RSCI/elibrary, over the past ten years.

Results. Using keywords, 215 articles were found and analyzed, from which 70 of the most significant and reliable sources were selected. It was concluded that it is necessary to develop a panel of markers of endothelial damage, which together will provide high reliability and specificity for assessing the risk of developing sepsis and septic shock.

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About the authors

Tatyana I. Khomyakova

Research Institute of Human Morphology named after. acad. A.P. Avtsyn Federal State Budgetary Scientific Institution “Russian Scientific Center for Chemistry named after. acad. B.V. Petrovsky»

Email: tatkhom@yandex.ru
ORCID iD: 0000-0003-3451-1952

Senior Researcher of the Laboratory of Immunomorphology of Inflammation

Russian Federation, Moscow

Maksim A. Babaev

FGBNU «RNTsKh im. acad. B.V. Petrovsky»

Email: maxbabaev@mail.ru
ORCID iD: 0000-0002-4288-3791

Chief Researcher of the Department of Cardiac Resuscitation

Russian Federation, Moscow

Elena A. Ponomarenko

Research Institute of Human Morphology named after. acad. A.P. Avtsyn Federal State Budgetary Scientific Institution “Russian Scientific Center for Chemistry named after. acad. B.V. Petrovsky»

Email: ponomarenkoea75@mail.ru
ORCID iD: 0000-0002-9672-7145

Senior Researcher of the Laboratory of Immunomorphology of Inflammation

Russian Federation, Moscow

Yury N. Khomyakov

FBUN Central Research Institute of Epidemiology of Rospotrebnadzor

Author for correspondence.
Email: khomyakovyuri@yandex.ru
ORCID iD: 0000-0003-0540-252X

Head of the Laboratory of Molecular Microbiology and Epidemiology of Mycobacterial Infections

Russian Federation, Moscow

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