Prognostic significance of expression of signal molecules to evaluate the metastasis of carcinoma of various locations
- Authors: Novak-Bobarykina U.A.1, Dokhov M.A.2,3, Krylova Y.S.2,4, Kvetnaya T.V.1, Paltsev M.A.5,6
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Affiliations:
- Autonomous scientific non-profit organization of higher education Research Center “St. Petersburg Institute of Bioregulation and Gerontology”
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- Federal State Budgetary Educational Institution of Higher Education St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia
- Federal State Budgetary Educational Institution of Higher Education “First St. Petersburg State Medical University Academician named after I.P. Pavlov” Ministry of Health of Russia
- Federal State Budgetary Educational Institution of Higher Education “Moscow State University named after. M.V. Lomonosov”
- Federal State Autonomous Educational Institution of Higher Education “Russian Peoples’ Friendship University named after Patrice Lumumba”
- Issue: Vol 22, No 3 (2024)
- Pages: 28-33
- Section: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/633666
- DOI: https://doi.org/10.29296/24999490-2024-03-04
- ID: 633666
Cite item
Abstract
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process.
Purpose of the study: To evaluate the possibility of using the expression of sorcin, histamine and caldesmon to predict distant metastases of gastric, prostate and lung carcinomas.
Material and methods. The medical histories of 98 people and histological material from carcinomas of the stomach, prostate and lungs were studied. Using the method of immunohistochemistry, data were obtained on the relative area of expression of molecular markers in tumor cells – sorcin, histamine and caldesmon at various stages of tumor differentiation. Discriminant analysis was used to predict distant metastasis of carcinomas.
Results. It was found that the relative expression of sorcin, histamine and caldesmon is statistically significantly lower in tumors with a high degree of differentiation (G1–G2) than in low-grade ones (G3–G4). Moreover, the presence of metastases was registered only for tumors with a low degree of differentiation. The relative expression area of sorcin, histamine and caldesmon had a high correlation with tumor differentiation. To predict the occurrence of distant metastases based on the expression of biological markers, discriminant functions were generated. Evaluation of the resulting discriminant model showed the correctness of the forecast in 94.8% of cases.
Conclusion. The study found that high levels of the relative area of sorcin, histamine and caldesmon indicate low differentiation of adenocarcinomas in the stomach, prostate gland and lungs. These biological markers can be used to predict distant metastases for adequate selection of further treatment tactics.
Keywords
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About the authors
Ulyana A. Novak-Bobarykina
Autonomous scientific non-profit organization of higher education Research Center “St. Petersburg Institute of Bioregulation and Gerontology”
Author for correspondence.
Email: ulyana.boba0304@mail.ru
ORCID iD: 0000-0002-6984-2148
Researcher, Department of Cell Biology and Pathology
Russian Federation, Dynamo Ave., 3, St. Petersburg, 197110Mikhail A. Dokhov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia
Email: mad20@mail.ru
ORCID iD: 0000-0002-7834-5522
Senior Researcher at the Center for Molecular Biomedicine, associate Professor of the Department of Medical Informatics, Candidate of medical sciences
Russian Federation, Ligovsky Ave., 2–4, St. Petersburg, 191036; st. Litovskaya 2, St. Petersburg, 194100Yuliya S. Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education “First St. Petersburg State Medical University Academician named after I.P. Pavlov” Ministry of Health of Russia
Email: emerald2008@mail.ru
ORCID iD: 0000-0002-8698-7904
Senior Researcher, Center for Molecular Biomedicine, assistant of the Department of Pathological Anatomy, Candidate of Medical Sciences
Russian Federation, Ligovsky Ave., 2–4, St. Petersburg, 191036; st. Lev Tolstoy, 6–8, St. Petersburg, 197022Tatyana V. Kvetnaya
Autonomous scientific non-profit organization of higher education Research Center “St. Petersburg Institute of Bioregulation and Gerontology”
Email: kvetnaia@gerontology.ru
ORCID iD: 0000-0002-5587-9740
Head of the Laboratory of Biogerontology, Doctor of Biological Sciences, Professor
Russian Federation, Dynamo Ave., 3, St. Petersburg, 197110Mikhail A. Paltsev
Federal State Budgetary Educational Institution of Higher Education “Moscow State University named after. M.V. Lomonosov”; Federal State Autonomous Educational Institution of Higher Education “Russian Peoples’ Friendship University named after Patrice Lumumba”
Email: mpaltzev@gmail.com
ORCID iD: 0000-0002-1469-4934
Director, Center for Immunology and Molecular Biomedicine, Faculty of Biology, Leading Researcher, Scientific and Educational Resource Center “Innovative technologies of immunophenotyping, digital spatial profiling and ultrastructural analysis (Molecular morphology)”, Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor
Russian Federation, Leninskie Gory, 1, Moscow, 119234; st. Miklouho-Maklaya, 6, Moscow, 117198References
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