Characteristics of the gut microbiota of patients with dyspepsia

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Abstract

Introduction: Studying the relationship between functional dyspepsia and gut microbiota will provide insight into the role of individual microorganisms and their metabolic products in the development of this pathology. The aim of the study was to analyze the microbiota of patients diagnosed with functional dyspepsia.

Materials and methods: Using the Ion Torrent PGM platform, sequencing of the V3 region of the 16S rRNA gene was performed.

Results: Differential analysis of the abundance showed that patients with dyspepsia have Corynebacterium jeikeium and Eggerthella lenta bacteria in the intestines, which have previously been associated with a number of inflammatory diseases. A relationship was established between Erysipelotrichaceae UCG-003 bacterium, Fusicatenibacter saccharivorans and Turicibacter sanguinis and dyspepsia.

Conclusion: The fecal microbiota characteristics of patients with dyspepsia were studied. The results showed a relationship between individual species and this pathology. For the first time, the relationship between the species Erysipelotrichaceae UCG-003 bacterium, Fusicatenibacter saccharivorans and Turicibacter sanguinis and functional dyspepsia was demonstrated.

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About the authors

Inna Y. Burakova

Voronezh State University of Engineering Technologies

Author for correspondence.
Email: vitkalovai@inbox.ru
ORCID iD: 0000-0002-5881-0845

Junior Researcher, Laboratory of Metagenomics and Food Biotechnology

Russian Federation, Revolution av. 19, Voronezh, 394036

Maria V. Gryaznova

Voronezh State University of Engineering Technologies

Email: mariya-vg@mail.ru
ORCID iD: 0000-0003-2076-3868

Junior Researcher, Laboratory of Metagenomics and Food Biotechnology

Russian Federation, Revolution av. 19, Voronezh, 394036

Yulia D. Smirnova

Voronezh State University of Engineering Technologies

Email: dyd16@mail.ru
ORCID iD: 0000-0002-5820-1804

Junior Researcher, Laboratory of Metagenomics and Food Biotechnology

Russian Federation, Revolution av. 19, Voronezh, 394036

Polina D. Morozova

Voronezh State University of Engineering Technologies; Voronezh State University

Email: ms.cloud00.00@mail.ru
ORCID iD: 0009-0000-0075-9170

Engineer, Laboratory of Metagenomics and Food Biotechnology; Student of the Department of Genetics, Cytology and Bioengineering

Russian Federation, Revolution av. 19, Voronezh, 394036; Universitetskaya sq. 1, Voronezh, 394018

Pavel A. Chizhkov

Voronezh State University

Email: qooleer@yandex.ru
ORCID iD: 0000-0002-5626-0579

3rd year Postgraduate Student, Faculty of Medical and Biological Sciences, Department of Genetics, Cytology and Bioengineering

Russian Federation, Universitetskaya sq. 1, Voronezh, 394018

Svetlana N. Lagutina

Voronezh State Medical University Named after N.N. Burdenko

Email: svlagutina97@mail.ru
ORCID iD: 0000-0003-3730-5265

Assistant, Department of Outpatient Therapy

Russian Federation, Studencheskaya st. 10, Voronezh, 394036

Mikhail Y. Syromyatnikov

Voronezh State University of Engineering Technologies; Voronezh State University

Email: mihan.vrn@mail.ru
ORCID iD: 0000-0001-9028-0613

Leading Researcher, Laboratory of Metagenomics and Food Biotechnology; Associate Professor, Department of Genetics, Cytology and Bioengineering, Candidate of Biological Sciences, Associate Professor

Russian Federation, Revolution av. 19, Voronezh, 394036; Universitetskaya sq. 1, Voronezh, 394018

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Supplementary files

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2. Fig. 1. Characteristics of the microbiome composition of feces from patients with dyspepsia at the type level

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3. Fig. 2. Indicators of microbiome α-diversity in patients with dyspepsia and without gastrointestinal pathology

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4. Fig. 3. An indicator of microbiome β-diversity in patients with dyspepsia and those without gastrointestinal pathology

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5. Fig. 4. Characteristics of the microbiome in patients with dyspepsia

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