Changes in the quantitative composition of neuroglia in the prefrontal cortex of rats with modeled post-traumatic stress disorder


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Abstract

Introduction. Neuroglia plays an important role in maintaining the stable functioning of the CNS. Of particular importance are neuroglial cells in the organization of the immune system of the brain, activating both with physical, physiological damage, and with chronic stress or other extreme, including mental, effects. The aim of the study. Characterizing the state of neuroglia in the prefrontal cortex of rats with a simulated post-traumatic stress disorder is crucial for understanding the cellular mechanisms underlying the development of pathological behavioral disorders in PTSD. Methods. Animal model of PTSD. Immunohistochemistry. Results. Significant quantitative differences in astrocytes were detected in all three zones of the medial prefrontal cortex in experimental and control animals, namely: a decrease in the number of astrocytic cells and their density in the first group (p<0,05). Conclusion. In the animal model of PTSD, the decrease in the density of astrocytes in the medial prefrontal cortex of the rat brain, despite the heterogeneity in the quantitative changes in the astrocytic network of individual zones of brain, is a general phenomenon not specific to a specific zone.

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About the authors

G. M Khayrullina

Immanuel Kant Baltic Federal University

Email: guzzi@inbox.ru
A. Nevskogo str., 14, Kaliningrad, 236016, Russian Federation

I. A Vacoliuk

Immanuel Kant Baltic Federal University

Email: guzzi@inbox.ru
A. Nevskogo str., 14, Kaliningrad, 236016, Russian Federation

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