SASP of endothelium and vascular smooth muscle cells: role in the pathogenesis and therapy of atherosclerosis
- Authors: Savitsky D.V.1, Linkova N.S.1,2,3, Kozhevnikova E.O.1, Saraev G.B.1, Kozlov K.L.1,4, Kvetnoy I.M.5,6
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Affiliations:
- Saint Petersburg Institute of Bioregulation and Gerontology
- Academy of Postgraduate Education of FSBU FSCC of FMBA of Russia
- Belgorod National Research University
- S.M. Kirov Military Medical Academy
- Saint Petersburg State University
- Saint Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation
- Issue: Vol 20, No 4 (2022)
- Pages: 9-15
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2918/article/view/113775
- DOI: https://doi.org/10.29296/24999490-2022-04-02
- ID: 113775
Cite item
Abstract
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmacotherapy of atherosclerosis. In the formation of SASP endotheliocytes and vascular smooth muscle cells, an important role is played by an increase in the synthesis of pro-inflammatory cytokines (IL1, IL6, IL8, TNF, MCP), a decrease in the production of the anti-inflammatory cytokine IL4, apoptosis factors (p16, p53), activation thrombosis factor PAI-1, MMP and other signaling molecules. SASP of senescent cells alters the functions of their microenvironment and induces a chronic inflammatory response (inflamm-aging) that contributes to vascular damage. In experimental studies, some senolytic cardio- andgeroprotectors (metformin, resveratrol, digoxin, rapamycin, quercetin, etc.) prevent the formation of SASP by endothelial and smooth muscle cells and prevent the development of atherosclerosis. The search for substances that prevent the formation of SASP and prevent the development of atherosclerosis is an important goal of gerontology and molecular medicine.
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About the authors
Dmitrij Vladimirovich Savitsky
Saint Petersburg Institute of Bioregulation and Gerontology
Email: dmitrijsavitckij@yandex.ru
the researcher of the laboratory of Pathologic Physiology of Cardiovascular System
Russian Federation,Natalia Sergeevna Linkova
Saint Petersburg Institute of Bioregulation and Gerontology; Academy of Postgraduate Education of FSBU FSCC of FMBA of Russia; Belgorod National Research University
Email: miayy@yandex.ru
doctor of biological sciences, docent, the head of the laboratory of molecular mechanisms of aging; the senior scientific research of the laboratory “Problems of Aging”, professor of the Department of therapy, geriatrics and antiaging medicine
Russian Federation,Ekaterina Olegovna Kozhevnikova
Saint Petersburg Institute of Bioregulation and Gerontology
Email: katena_94@list.ru
PhD, the scientific researcher of the Laboratory of Biogerontology
Russian Federation,Gleb Borisovich Saraev
Saint Petersburg Institute of Bioregulation and Gerontology
Email: glebsaraev@gmail.com
the scientific researcher of the Laboratory of Biogerontology
Russian Federation,Kirill Lenarovich Kozlov
Saint Petersburg Institute of Bioregulation and Gerontology; S.M. Kirov Military Medical Academy
Email: kozlov_kl@mail.ru
MD, doctor of medical sciences, professor, the head of the department of Clinical Gerontology and Geriatry
Russian Federation,Igor Moiseevich Kvetnoy
Saint Petersburg State University; Saint Petersburg Research Institute of Phthisiopulmonology of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: info@spbniif.ru
Head of the Center of Molecular Biomedicine, Professor, Doctor of Medical Sciences, Honored Worker of Science of the Russian Federation
Russian Federation,References
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