Assessment of C-reactive protein, presepsin and lipopolysaccharide-binding protein levels in cardiac surgery patients with postoperative infectious-inflammatory complications

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Abstract

Introduction Postoperative infectious and inflammatory complications worsen the prognosis of patients, increase the duration of hospitalization and increase the cost of treatment, therefore, the search for markers to determine the degree of risk of their development is an urgent problem. The prognostic differentiating biomarkers presumably include presepsin and lipolysaccharide-binding protein, the dynamics of which in serum correlates with the severity of the infectious and inflammatory reaction.

The aim: to conduct a pilot study to assess the dynamics of C-reactive protein, presepsin and lipolysaccharide-binding protein before surgery and on days 1 and 3 after cardiac surgery.

Material and methods: the study was conducted on blood serum samples of male patients of the cardiac surgery department (n=27) with and without developed infectious inflammatory complications.

Results: a significant increase in C-reactive protein was revealed on day 3 in all patients after cardiac surgery, while the further dynamics of C-reactive protein in patients with infectious complications differed from that in patients with a successful course of the postoperative period. In patients who did not have infectious and inflammatory complications, presepsin levels significantly increased compared to the baseline level on the first day after surgery, unlike patients who had complications. The value of the lipopolysaccharide-binding protein did not significantly differ between the groups.

Conclusion: C-reactive protein and presepsin can be regarded as significant diagnostic markers of inflammation, their dynamics may indicate the development of a postoperative infectious and inflammatory complication. The lipolysaccharide-binding protein does not exhibit biomarker properties in this aspect due to a significant individual variation.

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About the authors

Tatyana Ivanovna Khomyakova

Federal State Budgetary Scientific Institution “Russian Scientific Center of Surgery named after academician B.V. Petrovsky”

Email: tatkhom@yandex.ru
ORCID iD: 0000-0003-3451-1952

Research Institute of Human Morphology named after academician A.P. Avtsyn, Senior Researcher, Candidate of Medical Sciences

Russian Federation, Moscow, 117418, Tsyurupy str., 3

Liubov Vladimirovna Ozeretskaya

Federal State Budgetary Scientific Institution “Russian Scientific Center of Surgery named after academician B.V. Petrovsky”

Email: lozloz.o@yandex.ru
ORCID iD: 0009-0007-8646-3952

Junior Researcher, Research Institute of Human Morphology named after academician A.P. Avtsyn

Russian Federation, Moscow, 117418, Tsyurupy str., 3

Olga Vasilyevna Makarova

Federal State Budgetary Scientific Institution “Russian Scientific Center of Surgery named after academician B.V. Petrovsky”

Author for correspondence.
Email: makarov.olga2013@yandex.ru
ORCID iD: 0000-0001-8581-107X

Head of the laboratory, Chief Researcher, Research Institute of Human Morphology named after academician A.P. Avtsyn, Doctor of Medical Sciences

Russian Federation, Moscow, 117418, Tsyurupy str., 3

Marina Anatolyevna Diatroptova

Federal State Budgetary Scientific Institution “Russian Scientific Center of Surgery named after academician B.V. Petrovsky”

Email: diatrop@inbox.ru
ORCID iD: 0000-0002-0858-8369

Researcher, Research Institute of Human Morphology named after academician A.P. Avtsyn

Russian Federation, Moscow, 117418, Tsyurupy str., 3

Yuri Nikolaevich Khomyakov

Private Educational Establishment of High Education “University Synergy”

Email: khomyakovyuri@yandex.ru
ORCID iD: 0000-0003-0540-252X

Professor of the Department of Biomedical Sciences, Doctor of Biological Sciences, Candidate of Medical Sciences

Russian Federation, 125190, Moscow, Leningradsky Prospekt, 80, build. G

References

  1. Amanai E., Nakai K., Saito J., Hashiba E., Miura T., Morohashi H. et al. Usefulness of presepsin for the early detection of infectious complications after elective colorectal surgery, compared with C-reactive protein and procalcitonin. Sci Rep. 2022; 12 (1): 3960. doi: 10.1038/s41598-022-06613-w
  2. Lu C.Y., Kao C.L., Hung K.C., Wu J.Y., Hsu H.C., Yu C.H., Chang W.T., Feng P.H., Chen I.W. Diagnostic efficacy of serum presepsin for postoperative infectious complications: a meta-analysis. Front Immunol. 2023; 12 (14): 1320683. doi: 10.3389/fimmu.2023.1320683
  3. Tsimikas S., Willerson J.T., Ridker P.M. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J. Am. CollCardiol. 2006; 47: 31.
  4. Kushner I., Broder M.L., Karp D. Control of the acute phase response. Serum C-reactive protein kinetics after acute myocardial infarction. J. Clin. Invest. 1978; 61: 235–42.
  5. Shetty S., Ethiraj P., Shanthappa A.H. C-reactive Protein Is a Diagnostic Tool for Postoperative Infection in Orthopaedics. Cureus. 2022; 14 (2): e22270. doi: 10.7759/cureus.22270.
  6. Mierzchała-Pasierb M., Lipińska-Gediga M. Sepsis diagnosis and monitoring – procalcitonin as standard, but what next? Anaesthesiol Intensive Ther. 2019; 51 (4): 299–305. doi: 10.5114/ait.2019.88104.
  7. Zeng G., Chen D., Zhou R., Zhao X., Ye C., Tao H., Sheng W., Wu Y. Combination of C-reactive protein, procalcitonin, IL-6, IL-8, and IL-10 for early diagnosis of hyperinflammatory state and organ dysfunction in pediatric sepsis. J. Clin. Lab Anal. 2022; 36 (7): e24505. doi: 10.1002/jcla.24505.
  8. Herzum I., Renz H. Inflammatory markers in SIRS, sepsis and septic shock. Curr Med Chem. 2008; 15 (6): 581–7. doi: 10.2174/092986708783769704
  9. Gonzalez-Quintela A., Alonso M., Campos J., Vizcaino L., Loidi L., Gude F. Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity. PLoS One. 2013; 8 (1): e54600. doi: 10.1371/journal.pone.0054600.
  10. Citronberg J.S., Wilkens L.R., Lim U., Hullar M.A., White E., Newcomb P.A., Le Marchand L., Lampe J.W. Reliability of plasma lipopolysaccharide-binding protein (LBP) from repeated measures in healthy adults. Cancer Causes Control. 2016; 27 (9): 1163–6. doi: 10.1007/s10552-016-0783-9.
  11. Endo S., Suzuki Y., Takahashi G., Shozushima T., Ishikura H., Murai A. et al. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J infection chemotherapy Off J. Japan Soc Chemotherapy. 2012; 18 (6): 891–7. doi: 10.1007/s10156-012-0435-2
  12. Chenevier-Gobeaux C., Borderie D., Weiss N., Mallet-Coste T., Claessens Y.E. Presepsin (sCD14-ST), an innate immune response marker in sepsis. Clinicachimicaacta; Int. J. Clin. Chem. 2015; 450: 97–103. doi: 10.1016/j.cca.2015.06.026
  13. Efremova I., Maslennikov R., Poluektova E., Medvedev O., Kudryavtseva A., Krasnov G., Fedorova M., Romanikhin F., Zharkova M., Zolnikova O., Bagieva G., Ivashkin V. Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis. World J. Hepatol. 2024; 16 (5): 822–31 doi: 10.4254/wjh.v16.i5.822
  14. Жилинский Е.В. Применение пресепсина в диагностике и мониторинге эффективности лечения сепсиса при ожоговой болезни. Наука и инновации. 2016; 164. URL: https://cyberleninka.ru/article/n/primenenie-presepsina-v-diagnostike-i-monitoringe-effektivnosti-lecheniya-sepsisa-pri-ozhogovoy-bolezni (дата обращения: 25.10.2024). [Zhilinskij E.V. Primenenie presepsina v diagnostike i monitoringe effektivnosti lecheniya sepsisa pri ozhogovoj bolezni. Nauka i innovacii. 2016; 164. date of application25.10.2024). (in Russian)]
  15. Simonyan T.A., Bockeria L.A., Scopin I.I., Tsiskaridze I.M., Kakhktsyan P.V., Farulova I.Yu., Spirin L.V., Ibragimov M.S. Pre- and postoperative risk factors for hospital complications upon atypically localized left atrial myxomas. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2024; 28 (2): 30–40. https://doi.org/10.21688/1681-3472-2024-2-30-40
  16. Asada M., Oishi E., Sakata S. et al. Serum lipopolysaccharide‐binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the hisayama study. J. Am. Heart Assoc. 2019; 8: 13628. doi: 10.1161/JAHA.119.013628
  17. Chisari E., Cho J., Wouthuyzen-Bakker M., Parvizi J. Gut permeability may be associated with periprosthetic joint infection after total hip and knee arthroplasty. Sci Rep. 2022; 12 (1): 15094. doi: 10.1038/s41598-022-19034-6.
  18. Jeong Y.K., Kim E.Y. Predictive role of changes in presepsin and early sepsis in ICU patients after abdominal surgery. J. Surg Res. 2022; 278: 207–15. doi: 10.1016/j.jss.2022.04.072
  19. Imai Y., Tanaka R., Honda K., Matsuo K., Taniguchi K., Asakuma M. et al. The usefulness of presepsin in the diagnosis of postoperative infectious complications after gastrectomy for gastric cancer: a prospective cohort study. Sci Rep. 2022; 12 (1): 21289. doi: 10.1038/s41598-022-24780-8
  20. Hosokawa K., Obara H., Fukuda K., Mastubara K., Kitagawa Y. Specificity of Presepsin as a Biomarker of Bacterial Infection in Mouse Sepsis Models. J. Surg Res. 2023; 283: 572–80. doi: 10.1016/j.jss.2022.10.063.

Supplementary files

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2. Table 1 Characteristics of patient groups; Me (25–75%)

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3. Table 2 The value of the level of C-reactive protein in the blood serum of patients without complications (group 1) and with complications (group 2) at 3rdand 6thdays after surgery*

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4. Table 3 Changes in the level of LPS-binding protein in the blood serum of patients without complications (group 1) and with complications (group 2) on the 1stand 3rddays after surgery compared with the baseline

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5. Table 4 The values of presepsin levels in the blood serum of patients without complications (group 1) and with complications (group 2) on the 1stand 3rddays after surgery compared with the baseline

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