Sirtuins: predictive molecular diagnosis of Alzheimer’s disease in long-liver

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The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compare saliva concentration of sirtuins of long-liver in early AD stage and people without neuropathology. Methods. All long-liver were divided into 2 groups: «norm» (90-94 years old, n=14) and AD patients (90-95years old, n=15). The «norm» group includes persons without neuropathology and other somatic diseases in the acute phase. Saliva concentration of Sirt1, Sirt3, Sirt5, Sirt6 was measured by enzyme immunoassay method. Results. Saliva concentration of Sirt1, Sirt3 and Sirt6 AD patients was in 2.0, 3.7 and 3.0 times lower in comparison with corresponding parameter in the group «norm». Saliva concentration of Sirt5 of long-liver with Alzheimer’s disease and without neuropathology had no significant difference. Conclusion. Saliva concentration of Sirt1, Sirt3, Sirt6 assessment in the saliva of long-liver can apply as one of the criteria of molecular early AD diagnostic.

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作者简介

Anastasiia Pukhalskaya

Saint Petersburg Institute of Bioregulation and Gerontology

编辑信件的主要联系方式.
Email: nastyapuh96@mail.ru

the scientific research of the laboratory of molecular mechanisms of aging

Natalia Linkova

Saint Petersburg Institute of Bioregulation and Gerontology; Academy of postgraduate education underFSBU FSCC of FMBA of Russia; Belgorod National Research University

Email: miayy@yandex.ru

the head of the laboratory of molecular mechanisms of aging; professor of the Department of therapy, geriatrics and antiaging medicine of Academy of postgraduate education; Senior researcher of the Laboratory “Problem of Aging”

Roman Umnov

Saint Petersburg Institute of Bioregulation and Gerontology

Email: t.kmb@mail.ru

the scientific researcher of the Laboratory of Biogerontology of the Department of Biogerontology

Kirill Kozlov

Saint Petersburg Institute of Bioregulation and Gerontology

Email: kozlov_kl@mail.ru

the head of the Department of Clinical Gerontology and Geriatry

Igor Kvetnoy

Saint Petersburg State University; Saint Petersburg Scientific Research Institute of Phthisiopulmonology

Email: info@spbniif.ru

Head of the Center of Molecular Biomedicine; Рrofessor of the Department of Pathology

Mikhail Paltsev

Moscow State University

Email: mpaltz.ev@gmail.com

Director of Center of Immunology and Molecular Biomedicine

参考

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2. Saliva’s sirtuins concentration in long-liver without neuropathology (the group «norm») and in persons with Alzheimer disease (AD) Note. * – р<0.05 in comparison with the corresponding value in the group «norm».

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