Stimulating effect of encoded amino acids combinations on cellular proliferation in organotypic culture of tissue
- 作者: Chalisova N.I.1,2, Ryzhak G.A.2
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隶属关系:
- Pavlov Institute of Physiology, Russian Academy of Sciences
- St. Petersburg Institute of Bioregulation and Gerontology
- 期: 卷 22, 编号 3 (2024)
- 页面: 53-56
- 栏目: Reviews
- URL: https://journals.eco-vector.com/1728-2918/article/view/633670
- DOI: https://doi.org/10.29296/24999490-2024-03-08
- ID: 633670
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详细
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation balanced status in the organism tissues is one of the actual task of modern biology and medicine.
Purpose of study. Effect of encoded amino acids combinations on the cellular proliferation in tissues of different genesis.
Methods. Organotypic tissue culture of 5-month rat cerebral cortex (ectodermal genesis), myocardium (mezodermal genesis), pancreas (entodermal genesis) was used for quick screening of biologically activity of amino acids.
Results. The stimulating cellular proliferation effect of encoded amino acids combinations on tissues was established. The square index (SI) of explants was increased statistically reliable on 38–70%, as compared to the control.
Conclusion. The data obtained produce the base for working of preparations for treatment of patients with pathology in cerebral cortex, myocardium and pancreas tissues.
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作者简介
Natalia Chalisova
Pavlov Institute of Physiology, Russian Academy of Sciences; St. Petersburg Institute of Bioregulation and Gerontology
编辑信件的主要联系方式.
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
Expert scientific worker, Expert scientific worker of the laboratory of Oncogerontology of Biogerontology department, Doctor of biologic sciences, professor
俄罗斯联邦, emb. Makarova, 6, St. Petersburg, 199034; Dynamo Ave., 3, St. Petersburg, 197110
Galina Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: galina@gerontology.ru
ORCID iD: 0000-0003-2536-1438
associate Director of Institute, Doctor of medical sciences, рrofessor
俄罗斯联邦, Dynamo Ave., 3, St. Petersburg, 197110参考
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