Impact of plasmapheresis on intraorgan blood flow of the transplanted kidney in the early postoperative period
- Authors: Vatazin A.V1, Sinyutin A.A1, Zulkarnaev A.B1, Kantaria R.O1, Krstich M.1
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Affiliations:
- M.F. Vladimirsky Moscow Regional Research Clinical Institute
- Issue: No 1 (2014)
- Pages: 16-19
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/280094
- ID: 280094
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Abstract
Kidney transplant is inevitably subjected to ischemic and reperfusion injury. In many cases, this is due to a violation of intraorgan hemodynamics. Severity of such damage can be reduced using different methods of extracorporeal hemocorrection. The aim of the study was to examine the intraorgan blood flow of kidney transplant and assess the impact of plasmapheresis on its primary function in the early postoperative period. Plasmapheresis with replacement from 1,25 to 3,5 liters of plasma was applied in 40 recipients of the Group 1; in 40 recipients of Group 2 plasmapheresis was not performed. High resistance index (Ri> 0,9) at low flow velocities in the interlobular arteries at the first day after surgery is an informative criterion for the diagnosis of acute tubular necrosis and indicates the inadequate blood supply of kidney. Plasmapheresis has promoted the normalization of renal hemodynamics. Immediate graft function in patients of Group 1 was observed in 36 patients, whereas only in 19 patients of Group 2. In the Group 1, there were no patients with primary non-functioning graft, while there were three such patients in Group 2. Thus, plasmapheresis in the early postoperative period, no later than 3-5 h after reperfusion of the graft, has a positive effect on the functional status of the transplanted kidney.
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About the authors
A. V Vatazin
M.F. Vladimirsky Moscow Regional Research Clinical InstituteSurgery Department of Transplantology and Dialysis
A. A Sinyutin
M.F. Vladimirsky Moscow Regional Research Clinical InstituteSurgery Department of Transplantology and Dialysis
A. B Zulkarnaev
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Email: 7059899@gmail.com
Associate Professor, Department of Transplantology, Nephrology, and Artificial Organs
R. O Kantaria
M.F. Vladimirsky Moscow Regional Research Clinical InstituteSurgery Department of Transplantology and Dialysis
M. Krstich
M.F. Vladimirsky Moscow Regional Research Clinical InstituteSurgery Department of Transplantology and Dialysis
References
- Bronzatto E.J., da Silva Quadros K.R., Santos R.L. et al. Delayed graft function in renal transplant recipients: risk factors and impact on 1-year graft function: a single center analysis. Transplant. Proc. 2009; 41(3): 849-851.
- Yarlagadda S.G., Coca S.G., Formica R.N. Jr. et al. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol. Dial. Transplant. 2009; 24(3): 1039-1047.
- Grosso G., Corona D., Mistretta A. et al. Delayed graft function and long-term outcome in kidney transplantation. Transplant. Proc. 2012; 44(7): 1879-1883.
- Cicora F., Roberti J., Lausada N. et al. Donor preconditioning with rabbit anti-rat thymocyte immunoglobulin ameliorates ischemia reperfusion injury in rat kidney transplantation. Transpl. Immunol. 2012; 27(1): 1-7.
- Cicora F., Roberti J., Vasquez D. et al. Preconditioning donor with a combination of tacrolimus and rapamacyn to decrease ischaemia-reperfusion injury in a rat syngenic kidney transplantation model. Clin. Exp. Immunol. 2012; 167(1): 169-177.
- Chatterjee P.K. Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review. Naunyn Schmiedebergs Arch. Pharmacol. 2007; 376(1-2): 1-43.
- Thuillier R., Renard C., Rogel-Gaillard C. et al. Effect of polyethylene glycol-based preservation solutions on graft injury in experimental kidney transplantation. Br. J Surg. 2011; 98(3): 368-378.
- Zaouali M.A., Ben Abdennebi H., Padrissa-Altés S. et al. Pharmacological strategies against cold ischemia reperfusion injury. Expert. Opin. Pharmacother. 2010; 11(4): 537-555.
- Lam V.W., Laurence J.M., Richardson A.J. et al. Hypothermic machine perfusion in deceased donor kidney transplantation: a systematic review. J Surg. Res. 2013; 180(1): 176-182.
- Hosgood S.A., Nicholson H.F., Nicholson M.L. Oxygenated kidney preservation techniques. Transplantation. 2012; 93(5): 455-459.
- Sutherland T., Temple F., Chang S. et al. Sonographic evaluation of renal transplant complications. J Med Imaging Radiat Oncol. 201; 54(3): 211-218.
- Mehrsai A., Salem S., Ahmadi H. et al. Role of resistive index measurement in diagnosis of acute rejection episodes following successful kidney transplantation. Transplant Proc. 2009; 41(7): 2805-2807.
- Adibi A., Ramezani M., Mortazavi M., Taheri S. Color Doppler indexes in early phase after kidney transplantation and their association with kidney function on six month follow up. Adv. Biomed. Res. 2012; 1: 62.
- Impedovo S.V., Martino P., Palazzo S. et al. Value of the resistive index in patient and graft survival after kidney transplant. Arch. Ital. Urol. Androl. 2012; 84(4): 279-282.
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