EFFECT OF SIMVASTATIN ON ENDOTHELIUM-DEPENDENT VASODILATATIONOF CEREBRAL VESSELS IN ANIMALS WITH STREPTOZOTOCIN-INDUCEDDIABETES MELLITUS
- Authors: Tyurenkov IN1, Voronkov A.V.1, Tyurenkov IN1, Voronkov AV1
-
Affiliations:
- Issue: Vol 7, No 4 (2010)
- Pages: 87-89
- Section: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/118205
- ID: 118205
Cite item
Full Text
Abstract
It was revealed that administration of simvastatin prevents disorders in the NO-synthase system in cerebral vessels of animals with experimental diabetes. We can assume that endothelium-protective effect of simvastatin is associated with stabilization of NO-synthase system, which is manifested by an improvement of vasodilatating endothelial function and a decrease in the resistance and stiffness of the blood vessels in rats with hormonal disorders
About the authors
I N Tyurenkov
Andrey Vladislavovich Voronkov
Email: prohor.77@mail.ru <mailto:prohor.77@maii.ru>
I N Tyurenkov
A V Voronkov
References
- Воронков А. В., Робертус А. И., Тюренков И. Н. // Регионарное кровообращение и микроциркуляция. - 2008. - Т. 7, № 3. - С. 54-58.
- Тюренков И. Н., Воронков А. В. // Эксперим. и клинич. фармакология. - 2008. - Т. 71, № 1. - С. 49-51.
- Тюренков И. Н., Воронков А. В., Робертус А. И. // Регионарное кровообращение и микроциркуляция. - 2009. - Т. 29, № 1. - С. 50-53.
- Aikawa M., et al. // Circulation. - 2002. - Vol. 106. - P. 1390.
- Bakker W., Eringa C. Etto, Sipkema P. // Cell Tissue Res. - 2009. - № 335. - P. 165-189.
- Bode-Boger S. M. // Pharmacol Ther. - 2007. - Vol. 114 (3). - Р. 295-306.
- Cruickshank K., et al. // Circulation. - 2002. - Vol. 106. - № 16. - Р. 2085-2090.
- Haas M. J., et al. // Diabetes. - 2006. - № 55. - P. 474-479.
- Jorge P. A., et al. // Arq. Bras. Cardiol. - 2005. - Vol. 84, № 4. - P. 314-319.
- Van Nieuw Amerongen G. P., et al. // Circulation. - 2000. - Vol. 102. - P. 2803-2809.
Supplementary files
