REPROGRAMMING OF ALVEOLAR MACROPHAGES - NEW APPROACH TO IMMUNE RESPONSE MANAGEMENT


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Abstract

Macrophages play one of the central roles in the inflammation development obtaining pro-inflammatory M1 or anti-inflammatory M2 phenotype depending on the microenvironment. Some endogenous reprogramming macrophages factors (MRF), for example, TGF-p, SP-D, IL-4, INF-y can be found in serum. We demonstrated that decreasing and increasing of serum concentration and MRF respectively can purposefully reprogram macrophages phenotype to M1 or M2; and alveolar macrophages of two mice lines C57BL/6 and BALB/c were practically identical in their reprogramming ability. Our findings enlarge the existing data on the role of the environment in macrophages regulation and indicate new immunologic approaches to inflammatory lung diseases treatment.

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Copyright (c) 2011 Lyamina S.V., Kruglov S.V., Kalish S.V., Malyshev I.Y., Lyamina S.V., Kruglov S.V., Kalish S.V., Malyshev I.Y.

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