Comparative research of antihypertensive actionof cardos and lozartan
- 作者: Tyurenkov IN1, Nazvanova AV1, Chepurina NG1, Tyurenkov IN1, Nazvanova AV1, Chepurina NG1
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隶属关系:
- 期: 卷 3, 编号 3 (2006)
- 页面: 67-70
- 栏目: Articles
- URL: https://journals.eco-vector.com/1994-9480/article/view/117862
- ID: 117862
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The revealed hypotensive effect of oral ultralow doses (ULD) of antibodies to receptor type 1 AT II (cardos) in spontaneously hypertensive rats is a good foundation for a new class of hypotensive drugs. The detected hypotensive effect of ULD antibodies to components of renin-angiotensin system (RAS) may be due to modulating impacts of antibodies on the RAS. A significant decrease in systolic arterial blood pressure (SABP) was found in rats receiving cardos. Lozartan decreased SABP by 25 % and kept stable during the period of observation. ULD antibodies to receptor type 1 AT II (cardos) decreased SABP by 10 %. This hypotensive effect is of great interest in regard to developing original medicinal preparations of a new generation.
参考
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