Vol 3, No 3 (2006)

25 children and teenagers aged 11-16 with arterial hypertension accompanied by metabolic syndrome who received enalapril or bisoprolol as part of their therapy were studied. Administration of bisoprolol to children with metabolic syndrome has the advantage of minimal sympathic influence, which was evident from normal ABP daily index and TMR and SMR values (Holter monitoring results) as well as a higher level of compliancy. Bisoprolol had no negative effect on corabohydrate or lipid metabolism. Enalapril therapy was followed by IMMLV decrease, which testifies to more pronounced organ-protecting properties of the drug. A strict recording of initial heart rate or of the state of intracardiac conductivity was not required. Insulin resistance decrease which is the main pathogenetic link of metabolic syndrome was also noted.

Over the past several years, 24-h ambulatory blood pressure monitoring (ABPM) has become a useful tool for the diagnosis and management of children and adolescents with elevated blood pressure (BP). In our study we investigated the applicability of ABPM in 25 healthy newborn, aged from 1 to 6 days. A satisfactory ABPM profile was obtained in 100 % of the children, with an average of 95 % satisfactory BP recordings. The mean ± SD systolic and diastolic BP of healthy newborn was 75 ± 12/46 ± 13 mmHg during the daytime and 73 ± 12/44 ± 13 mmHg during the night, with no gender difference observed. The 24-h mean ± SD systolic and diastolic BP, which may be a more appropriate measure of BP in this particular age group, was found to be 71 ± 15/41 ± 14 mmHg. There was only a slight nocturnal decrease in BP. We conclude that this method is applicable for the assessment of blood pressure in the newborn.

The application of the diagnostic complex "KID-3" in the investigation of people with different operator work efficiency enabled us to establish the essential difference in the mechanisms of the motor activity regulation. The results of the research showed that the functional organization of successful operator motor activities includes the signs of two systems of visual-motor coordination: the sensor correction type and the motor programming one. The revealed peculiarities of the motor activity regulation may be used for the physiological prognostication of the operator activity efficiency for professional selection.

Parameters of maxillary dental arch were studied on people with neutral bite aged 8-21. Regularities of onthogenetic processes of dental arch growth of maxilla, having practical value for optimization of technique and period of bite correction in people aged 8-21, were determined.

The role of dynamic eustress in development of adjuvant arthritis and rheumatoid arthritis has been studied. 30 laboratory male rats were studied. Parameters of dynamics of adjuvant arthritis, products of lipid metabolism and lipid peroxidation were registered. 45 patients with rheumatoid arthritis were surveyed. Development of adjuvant disease was accompanied by essential changes in dynamics of investigated parameters, including products of lipid peroxidation. Daily dynamic eustress decreased the development of systemic inflammation almost in all investigated parameters; it also decreased the level of products of lipid peroxidation. Positive stress in clinical setting (graduated exercise) also had a positive therapeutic effect.

Activation of free radical processes in the acute period of craniocereberal injury is combined with a disorder of contractile function of isolated rat hearts. Inhibition of lipid peroxidation processes with the help of antioxidant carnosin confirms the importance of this pathogenetic factor in formation of posttraumatic depression of myocardium contractility.

The transfer of RP4 and RP1:: Tn10 Rep ts plasmids to Burkholderia mallei Ц4 invoked occurrence of drug resistance determined by plasmid genes, to changes in composition of whole proteins and antigenic spectrum in transconjugants and also change of microbe sensitivity to melioidosis bacteriophages and decrease of virulence.

A study of rheological properties of sodium fluoride gel made it possible to determine the basis and rational composition of this drug form. Investigation of its anticaries effect has demonstrated a high activity which substantially exceeds the effect of fluoride varnish as a preventive drug.

The influence of oxinicotinic acid derivatives on the absorbing and metabolic activities of polynuclears of rats periferal blood in conditions of toxic lesion of liver (ССl4) has been studied. The oxinicotinic acid derivatives were established to possess different activity on the separate parameters of absorbtive activity of polynuclears of rats periferal blood with toxic lesion of the liver.

Modern approaches to the diagnostics of the chronic obstructive lung disease are being evaluated from the point of view of general practitioner.