INTRACELLULAR INFECTION: ROLE IN ISCHAEMIC HEART DISEASEDEVELOPMENT AND EXACERBATION


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Inflammation due to infection could be associated with the development of ischaemic heart disease (IHD) and acute
coronary syndrome (ACS). The aim was to determine whether respiratory and genitourinary mycoplasmal infection is connected with the development of ACS. Using a case-control study design, we evaluated the prevalence of respiratory and genitourinary infection among 116 patients with ACS, 82 pts with chronic IHD and 50 controls without IHD. Moreover we examined the presence of several type of Mycoplasma and the level of specific antibodies in ACS patients compared with
chronic IHD patients and controls. We revealed increased frequency of previous respiratory infection in ACS patients. Acute
infection or activation of chronic infection was 2 times more common in ACS. The presence of M.pneumoniae and elevated
level of specific antibodies were found out in 25 and 72 % cases accordingly among ACS patients. These data suggest that
mycoplasmal infection may be involved in pathogenesis of ACS.

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版权所有 © Babaeva A.R., Balabanova E.N., Abrosimova E.V., Emel'yanova A.L., Babaeva A.R., Balabanova E.N., Abrosimova E.V., Emelianova A.L., 2010

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