Vol 7, No 3 (2010)

Recent data from literature on stress-induced modulation of the immunity and structure of the lymphoid organs are presented in the article.

This paper presents a pharmacoeconomic analysis of patients with chronic idiopathic urticaria on the background of the treatment of various anti-allergic drugs.

Inflammation due to infection could be associated with the development of ischaemic heart disease (IHD) and acute coronary syndrome (ACS). The aim was to determine whether respiratory and genitourinary mycoplasmal infection is connected with the development of ACS. Using a case-control study design, we evaluated the prevalence of respiratory and genitourinary infection among 116 patients with ACS, 82 pts with chronic IHD and 50 controls without IHD. Moreover we examined the presence of several type of Mycoplasma and the level of specific antibodies in ACS patients compared with chronic IHD patients and controls. We revealed increased frequency of previous respiratory infection in ACS patients. Acute infection or activation of chronic infection was 2 times more common in ACS. The presence of M.pneumoniae and elevated level of specific antibodies were found out in 25 and 72 % cases accordingly among ACS patients. These data suggest that mycoplasmal infection may be involved in pathogenesis of ACS.

Simple parallel group randomized investigation was performed. Ivabradin (or verapamil SR were administered for 4week treatment of postMI silent ischemic patients with stable angina (class I-II) and concomitant controlled/partly controlled bronchial asthma or moderate/severe chronic obstructive pulmonary disease. Both drugs have demonstrated the same resting HR reduction, antianginal/antiischemic activity, tolerance of physical exertion improvement.

The results of treatment of 230 patients with obstructive jaundice complicated by purulent cholangitis are analyzed. The advantages of nasobiliary draining in addition to endoscopic transpapillary procedures are demonstrated. The efficacy of epidural anesthesia in prevention of development of acute postoperative pancreatitis is proved.

60 families were examined: probands and relatives of I, II and III relation degrees. The family selection was carried out according to the proband (children at the age of 3-6) with the echocardiographic signs of mitral valve prolapse and/or anomalously located chorda. The results of examination of 360 people (61 -proband, 123 -relatives of the I relation degree, 172 -relatives of the II relation degree, 4 -relatives of the III relation degree) showed that the hereditary nature of connective tissue dysplasia with prevalence of so-called «maternal effect» was established in most cases. The high occurence of external mesenchymal signs in children can be explained by the genetic material storage across the generations.

The modelling of deficiency of oxide nitrogen introduction L-NAME to rats led to development of arterial hypertension, increase in the factor of endothelial dysfunction, decrease in the maintenance of nitrates/nitrites levels, hypertrophy of cardiomyocytes. Introduction of donors NO, activators of No-sintase, antioxidants, antihypertensive drugs has revealed comparable endotelioprotective effects.

The present work is devoted to studying the possibility of using low-frequency bioresonance for correction of operators work efficiency at various degrees of success and various levels of emotional intelligence. We determined the features of operators intellectual sphere and showed that a high level of emotional intelligence is the integral part of effective operators activity. As a result of using a course of low-frequency bioresonance on CNS, EEG-signs of activation of the cortex in unsuccessful operators and decrease of subcortical brain structures activity were revealed.

Authors have examined and treated 48 patients with abdominal sepsis. It was shown that including plasmapheresis in the complex therapy scheme had a positive effect on the parameters of central and peripheral hemodynamics and also improved energetic processes in the myocardium and functional condition of organs and systems in general.

A technique of immunoenzyme evaluation of antibodies (AB) to thyroid hormones (conjugated T4 and conjugated T3) on the base of immobilized magnetic sorbents, which may be used in clinical laboratories, was elaborated for the first time. AB to conjugated T4 and conjugated T3 was revealed in sera of rheumatoid arthritis (RA) patients, their concentration correlated with the pathologic process activity. Level of AB to T4 and T3 differed significantly as compared with healthy persons. Evaluation of AB to thyroid hormones may be used as a complementary test in complex diagnosis in order to characterize the activity of pathologic process and clinical forms of RA.

The paper presents basic epidemiological caries indices in primary schoolchildren. We studied children's oral health peculiarities and analyzed the effectiveness of dental treatment

Drug utilization review study is an important component of improvement of medical aid quality. As a result of the conducted pharmacoepidemiological comparative analysis between hospitals of various levels, some differences in quality, quantity and intensity of medications administration in the treatment of patients with bronchial asthma and chronic obstructive pulmonary disease have been revealed and consumption tendencies in the most significant pharmacotherapeutic groups have been established.

The results of studies of hemodynamic postprandial period in patients with duodenal ulcera are presented.

We demonstrated an increase in occupational morbidity in the Samara region, including occupational groups of health care workers, which is due to accumulated morbidity and increased effectiveness of work, as w ell as greater awareness of workers of occupational disease.

On the grounds of the obtained results we think it reasonable that Doppler sonography in complex with other methods can be used to advantage for differential diagnostics of benign uterine and ovarian neoplasms. Reliability of Doppler sonography diagnostics mostly depends on the possibilities of the ultrasonic equipment and its optimum adjustment, as well as on the methods of Doppler investigation. Complex use of ultrasonic (transvaginal sonography) and Doppler sonography methods allowed us to raise the accuracy of the diagnostics of the pathological process of genitals to 99.9 %.

A short review of pathohistological diagnostic criteria of biopsy and autopsy material of pancreas and kidneys from patients with diabetes mellitus is given. A description of pathohistological algorithm using modern pathoanatomical methods is presented.