THE VOXEL-BASED MORPHOMETRY AND DIFFUSION-TENSOR IMAGINMETHODS IN DIAGNOSTICS OF DEPRESSIVE DISORDERS


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32 depressive patients were investigated using several neuroimaging methods. Functional and structural abnormalities
were established in limbic structures in all groups of patients. Almost all of these structures are parts of so-called frontal
sub-cortical circuits. The structural neural imaging results (voxel-based morphometry, diffusion-tensor imaging) revealed
tracts deficiency in fornix, callous corpus and cingilate convolutions. Observed similar changes (for patients with different
depression types) can be a neural biological substrate of depression syndrome of different genesis, and identified differences
may indicate that depression can be caused by various pathological processes.

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