EFFICIENCY OF ESOMEPRAZOLE AS AN INITIAL THERAPY OF ESOPHAGITIS IN THE ELDERLY PATIENTS


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Abstract

The clinical trial has examined 52 elderly patients with erosive esophagitis treated with esomeprazole 40 mg/day for 8 weeks, and 50 patients with the same disease treated with omeprazole 40 mg/day. After 4 weeks of treatment, recovery was observed in 94.2% of patients treated with esomeprazole and in 70.0% of individuals in the group treated with omeprazole (P<0.001). After 8 weeks of treatment, the there were 96.2 and 80.0%, respectively (P<0.001). The advantage of esomeprazole was especially pronounced in grade C and D esophagitis according to Los Angeles classification. It was concluded that esomeprazole in the treatment of erosive esophagitis in elderly patients has a higher efficiency compared with omeprazole.

References

  1. Машарова А.А. Повышение эффективности и безопасности фармакотерапии ГЭРБ у пожилых // Клиническая геронтология 2005. № 9. С. 31-2.
  2. Pilotto A, Franceschi M, Leandro G, et al. Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients. J Am Geriatr Soc 2006;54(5):1537-42.
  3. Vakil N, van Zanten S, Kahrilas P, et al. The Monreal Definition and Classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101(8):1900-20.
  4. Lundell LR, Dent J, Bennet JR. Endoscopic assessment of oesophagitis clinical and fuctional correlates and futher validation of Los Angeles classification. Gut 1999;45(2):72-180.
  5. Heikkila S. The Dougados Functional Index with the 5-point Likert scale is sensitive to change due to intensive physiotherapy and exercise in spondyloarthropathy. Clin Exp Rheumatol 2002;5(3):689-92.
  6. Richter JE, Kahrilas PJ, Johanson J, et al. Efficacy and safety of esomepazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial. Am J Gastroenterol 2001;96(3):656-65.
  7. Labenz J, Armstrong D, Lauritsen K, et al. A randomized comparative study of esomepazole 40 mg versus pantoprazole 40 mg for healing erosive esophagitis: the EXPO study. Aliment Pharmacol Ther 2005;21(6):739-46.
  8. Lauritsen K, Deviere J, Bigard MA, et al. Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results. Aliment Pharmacol Ther 2003;17(3):333-41.
  9. Edwards SJ, Lind T, Lundell L, et al. Systematic review: standard- and double-dose proton pump inhibitors for the healing of severe erosive oesophagitis - a mixed treatment comparison of randomized controlled trials. Aliment Pharmacol Ther 2009;30(6):547-56.

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