EFFICIENCY OF ESOMEPRAZOLE AS AN INITIAL THERAPY OF ESOPHAGITIS IN THE ELDERLY PATIENTS


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Abstract

The clinical trial has examined 52 elderly patients with erosive esophagitis treated with esomeprazole 40 mg/day for 8 weeks, and 50 patients with the same disease treated with omeprazole 40 mg/day. After 4 weeks of treatment, recovery was observed in 94.2% of patients treated with esomeprazole and in 70.0% of individuals in the group treated with omeprazole (P<0.001). After 8 weeks of treatment, the there were 96.2 and 80.0%, respectively (P<0.001). The advantage of esomeprazole was especially pronounced in grade C and D esophagitis according to Los Angeles classification. It was concluded that esomeprazole in the treatment of erosive esophagitis in elderly patients has a higher efficiency compared with omeprazole.

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