APPLICATION OF NSAIDS IN THE TREATMENT OF PAIN SYNDROMES
- Authors: Kotova O.V.1, Kotova OV1
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Affiliations:
- Issue: No 19 (2011)
- Pages: 45-48
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279120
- ID: 279120
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Abstract
A fundamental aspect of the problem of pain is its division into two types - acute and chronic; mechanisms of development and approaches to treatment of these types of pain are fundamentally different. To date, more than 30 compounds involved in the mechanisms of excitation and inhibition of nociceptive neurons in the central nervous system are identified. Reduction of synthesis of inflammatory mediators leads to significant analgetic effect. Non-narcotic analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) have such mechanism of action. In modern medicine, priority is given to NSAID that selectively inhibits cyclooxygenase-2 (COX-2); in contrast to the nonselective COX inhibitors, they have significantly less side effects.
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References
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