Istoriya i budushchee tuberoznogo skleroza

In recent decades, research on the mechanism of malignant transformation led to the identification of a number of signaling pathways responsible for the regulation of tumor cell proliferation. Initiated by growth factors, hormones or cytokines, such signaling pathways usually start with tyrosine kinase cascade and result in activation of various families of transcription factors that control gene expression in cell division. Identification of these activated signaling pathways in carcinogenesis and suppression of their activity is one of the urgent problems of modern systemic targeted therapy. A description of the key role of PI3K/Akt/mTOR signaling cascade in the pathogenesis of tuberous sclerosis, that responsible for the integration of proliferative stimuli and activation of protein translation, has allowed to plan and begin clinical studies on the effectiveness of mTOR inhibitors as drugs for pathogenetic therapy tuberous sclerosis.

tuberous sclerosis, TSC1/2 genes, hamartin, tuberin, PI3K/Akt/mTOR signaling pathway, everolimus, sirolimus