Znachenie malykh bronkhov pri nekotorykh fenotipakh astmy i effektivnost' ekstramelkodispersnogo ingalyatsionnogo kortikosteroida tsiklesonid


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

This article is devoted to the discussion of possible ways to optimize the current level of asthma control in patients taking into account, on the one hand, the phenotypic heterogeneity of the disease, and on the other hand - the ability to impact on the peripheral airways (small bronchi). Finely-divided inhaled corticosteroid ciclesonide, which has a large lung fraction, more than half of which is distributed in the distal bronchi, is effective in achieving and maintaining control of asthma in children, adolescents and adults. High safety of the drug includes the lack of systemic effects and a low incidence of local oropharyngeal reactions.

Full Text

Restricted Access

About the authors

N. M Nenasheva

References

  1. Адо А.Д., Булатов П.К. Клинико-физиологические основы классификации бронхиальной астмы. В кн.: Материалы к V межобластной научной конференции терапевтов. Этиология, патогенез, клиника и лечение заболеваний органов дыхания / Под ред. П.К. Булатова. Л., 1969. С. 258-65.
  2. Федосеев Г.Б. Современное представление о причинах возникновения, особенностях течения и лечения бронхиальной астмы. Актовая речь. Л., 1982. 28 с.
  3. Wenzel S. Asthma: defining of the persistent adult phenotypes. Lancet 2006;368:804-13.
  4. www.ginasthma.com
  5. Johansson SG, Hourihane J, Bousquet J, et al. A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813-24.
  6. Bateman ED, et al. Can guideline-defined asthma control be achieved? Am J Respir Crit Care Med 2004;170:836-44.
  7. Bateman ED, et al. Stability of asthma control with regular treatment: an analysis of GOAL study. Allergy 2008;63:932-38.
  8. Demoly P, Gueron B, Annunziata K, et al. Update on asthma control in five European countries: results of a 2008 survey. Eur Respir Rev 2010;19;116:150-57.
  9. Liu AH, Gilsenan AW, Stanford RH, et al. Status of asthma control in pediatric primary care: results from the pediatric Asthma Control Characteristics and Prevalence Survey Study (ACCESS). J Pediatr 2010;157:276-81.
  10. Haughney J, Price D, Kaplan A, et al. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med 2008;102(12):1681-93.
  11. Allegra L, Cremonesi G, Girbino G, et al. Real-life prospective study on asthma control in Italy: Crosssectional phase results. Respiratory Medicine 2011;doi: 10.1016/j.rmed.201 1.10.001.
  12. Wenzel S. Asthma phenotypes: the evolution from clinical to molecular approaches. Nature Medicine 2012;18:716-25.
  13. Han MK, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 2010;182:598-604.
  14. Weibel ER. What makes a good lungs? Swiss Med WKLY 2009;139(27-38):375-86.
  15. Saetta M, Di Stefano, et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Resp Dis 1991;143:138-43.
  16. Carroll N, Cooke C, James A. The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 1997;10:292-300.
  17. Caroll N, Carello S, et al. Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J 1996;9:709-15.
  18. Mauad T, Silva LF, Santos MA, et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med 2004;170:857-62.
  19. Hamid QA, Song Y, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997;100:44-51.
  20. Balzar S, Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002;20:254-59.
  21. Hamid QA. Peripheral inflammation is more important than central inflammation. Respire Med 1997;91(Suppl. A):11-2.
  22. Mitchell HW, Cvetkovski R, et al. Concurrent measurement of smooth muscle shortening, lumen narrowing and flow to acetylcholine in large and small porcine bronchi. Eur Respir J 1998;12:1053-61.
  23. Ellis JL, Hubbard WC, et al. Ragweed antigen E and anti-IgE in human central versus peripheral isolated bronchi. Am J Respir Crit Care Med 1994;150:717-23.
  24. Mahut B, Delclaux C, Tillie-Leblond I, et al. Both inflammation and remodeling influence nitric oxide output in children with refractory asthma. J Allergy Clin Immunol 2004;113:252-56.
  25. Berry M, Hargadon B, Morgan A, et al. Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J 2005;25:986-91.
  26. Gershman NH, Liu H, Wong HH, Liu JT, Fahy JV. Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points. J Allergy Clin Immunol 1999;104:322-28.
  27. Richter K, Holz O, Jorres RA, Mucke M, Magnussen H. Sequentially induced sputum in patients with asthma or chronic obstructive pulmonary disease. Eur Respir J 1999;14:697-701.
  28. Taha R, Hamid Q, Olivenstein R. Fractional analysis of Th2-type cytokines in sequential samples of induced sputum. Can Respir J 2004; 11:146-50.
  29. Wagner EM, Bleecker ER, Permutt S, Liu MC. Direct assessment of small airways reactivity in human subjects. Am J Respir Crit Care Med 1998;157:447-52.
  30. Kraft M, Martin RJ, Wilson S, et al. Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. Am J Respir Crit Care Med 1999;159:228-34.
  31. Ueda T, Niimi A, Matsumoto H, et al. Role of small airways in asthma: investigation using highresolution computed tomography. J Allergy Clin Immunol 2006;118:1019-25.
  32. Sorkness RL, Bleecker ER, Busse WW, et al. Blood Institute Severe Asthma Research Program. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008;104:394-403.
  33. Busacker A, Newell JD Jr, Keefe T, et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest 2 009; 135:48- 56.
  34. Godard P, Chanez P, Siraudin L, et al. G. Costs of asthma are correlated with severity: a 1 -yr prospective study. Eur Respir J 2002; 19:61-7.
  35. Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-38.
  36. Balzar S, Chu HW, Strand M, Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005; 171:431 -39.
  37. Berry M, Hargadon B, Morgan A, et al. Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma Eur Respir J 2005;25:986-91.
  38. Sorkness R, Bleecker E, Busse W, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008;104:394-403.
  39. The ENFUMOSA Study Group. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 2003;22:470-77.
  40. Contoli M, Kraft M, Hamid Q, et al. Do small airway abnormalities characterize asthma phenotypes? In search of proof Clinical & Experimental Allergy 2012;42:1150-60.
  41. in 't Veen JC, Beekman AJ, Bel E, and Sterk P. Recurrent Exacerbations in Severe Asthma Are Associated with Enhanced Airway Closure During Stable Episodes. Am J Respir Crit Care Med 2000;161:1902-906.
  42. Kraft M, Pak J, Martin RJ, et al. Distal lung dysfunction at night in nocturnal asthma. Am J Respir Crit Care Med 2001 ; 163:1551 -56.
  43. Martin RJ, Sicutto LC, Smith HR, et al. Airways inflammation in nocturnal asthma. Am Rev Respir Dis 1991;143:351-57.
  44. Kraft M, Martin RJ, Wilson S, et al. Recurrent Exacerbations in Severe Asthma Are Associated with Enhanced Airway Closure During Stable Episodes. Am J Respir Crit Care Med 2000;161:1902-906.
  45. Djukanovic R, Holgate ST. Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. Am J Respir Crit Care Med 1999; 159:228-34.
  46. Lee JH, Haselhom T, Borish L, et al. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insight from the TENOR-study. Chest 2007;132:1882-89.
  47. ten Brinke A, Zwinderman AH, Sterk PJ, et al. Factors associated with persistent airflow limitation in severe asthma. Am J Resp Crit Care Med 2001;164:744-48.
  48. Bellia V, Cibella F, Cuttitta G, et al. Effect of age upon airway obstruction and reversibility in adult patients with asthma. Chest 1998; 114:1336-42.
  49. Cassino C, Berger KI, Goldring RM, et al. Duration of asthma and physiologic outcomes in elderly nonsmokers. Am J Respir Crit Care Med 2000;162:1423-28.
  50. Verbeken EK, Cauberghs M, Mertens I, et al. The senile lung. Comparison with normal and emphysematous lungs. 2. Functional aspects. Chest 1992;101:800-9.
  51. Verbeken EK, Cauberghs M, Mertens I, et al. The senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspects. Chest 1992;101:793-99.
  52. Sung-Woo Park, Jai-Soung Park, Sun Hye Jeong, et al. Air trapping is a major determinant of persistent airway obstruction in asthmatics. Respiratory Medicine 2012; 106,786-93.
  53. Esposito-Festen JE, Zanen P, Tiddens HAWM, Lammers JWJ. Pharmacokinetics of inhaled monodisperse beclomethasone as a function of particle size. Br J Clin Pharmacol 2007 64:328-34.
  54. Lindstrm M. Particles in small airways: mechanisms for deposition and clearance. Thesis, Stockholm: Karolinska Institute; 2004.
  55. Schuepp KG, Jauernig J, Janssens HM, et al. In vitro determination of the optimal particle size for nebulised aerosol delivery to infants. J Aerosol Med 2005;18:225-35.
  56. Colice GL. The newly developed inhaled cortico steroid ciclesonide for the treatment of asthma. Expert Opin Pharmacother 2006;7:2107-17.
  57. de Vries TW, Rottier BL, Gjaltema D, et al. Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution. Respiratory Medicine 2009;103:1167-73.
  58. Newman S, Salmon A, Nave R, et al. High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respire Med 2006;100(3):375-84.
  59. Adachi M, Ishihara K, Inoue H, et al. Efficacy and safety of ciclesonide compared with chlo-rofluorocarbone beclometasone dipropionate in adults with moderate to severe persistent asthma. Respirology 200 7; 12:5 73-80.
  60. Bateman ED, A.E. Linnhof AE, Homik L, et al. Comparison of twice-daily inhaled ciclesonide and fluticasone propionate in patients with moderate-to-severe persistent asthma. Pulm Pharmacol Ther 2008;21:264-75.
  61. Boulet LF, Bateman ED, Voves R, et al. A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respiratory Medicine 2007; 101:1677-86.
  62. Richter K, Kanniess F, Biberger C, et al. Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma. J Clin Pharmacol 2005;45(2):146-52.
  63. O'Connor BJ, Kilfeather S, Cheung D, et al. Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up. Expert Opin. Pharmacother 2010;11(17):1-13.
  64. Haughney J, Barnes G, Partridge M, Cleland J. The Living & Breathing Study: a study of patients' views of asthma and its treatment. Prim Care Respir J 2004;13:28-35.
  65. Cochrane GM, Horne R, Chanez P. Compliance in asthma. Respir Med 1999;93:763-69.
  66. Venables TL, Addlestone MB, Smithers AJ, et al. A comparison of the efficacy and patient acceptability of once daily budesonide via Turbuhaler and twice daily fluticasone propionate via disc-inhaler at an equal daily dose 400 mcg in adult asthmatics. Br J Clin Res 1996;7:15-32.
  67. Vermeulen JH, Gyurkovits K, Rauer H, Engelsta'tter R. Randomized comparison of the efficacy and safety of ciclesonide and budesonide in adolescents with severe asthma. Respiratory Medicine 2007;101:2182-91.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies