ESTROGENY I TsENTRAL'NAYa NERVNAYa SISTEMA


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Estrogens are involved in the development of brain structures that define a woman's behavior. They provide genomic and negenomic effects on the brain through binding to estrogen receptors. Neuronal and glial cells contain the enzyme aromatase for local estrogen synthesis. The article summarizes the protective effects of estrogen in degenerative processes of the central nervous system (CNS). The data on the use of estrogen in schizophrenia, migraine, and other pathological processes in the CNS are presented.

Full Text

Restricted Access

About the authors

V. P Smetnik

E. M Il'ina

References

  1. Aibertazzi P, Purdie DW. The life and times of the estrogen receptors: an interim report. Climacteric 2001;4:194-202.
  2. Kruijver FPM, Swaab DF. Sex Hormone Receptors are Present in the Human Suprachiasmatic Nucleus. Neuroendocrinoiogy 2002;75: 296-305.
  3. Osteriund MK, Keiier E, Hurd Yl. The human forebrain has discrete estrogen receptor aipha messenger RNA expression: high ieveis in the amygdaioid compiex. Neuroscience 2000;95:333-42.
  4. Scobie GA, Macpherson S, Miiiar MR, et ai. Human oestrogen receptors: differentiai expression of ER aipha and beta and the identification of ER beta variants. Steroids 2002;67:985-88.
  5. Studd JW. A guide to the treatment of depression in women by estrogens. Ciimacteric 2011 ;14(6):637-42.
  6. Birge SJ. Estrogen and the brain: impiications for menopause management. ln Menopause. The State of the Art in research and management. / Ed. P.G. Schneider. The Parthenon Pubiishing Group 2002;191-95.
  7. Bromberger JT, Meyer PM, Kravitz HM, et ai. Psychoiogicai distress and menopause: a muitiethnic community study. Am J Pubiic Heaith 2001;91:1435-42.
  8. Cohen LS, Soares CN, Vitonis AF, et ai. Risk for new onset of depression during the menopausai transition: the Harvard study of moods and cycies. Arch Gen Psychiatry 2006;63:385-90.
  9. Freeman EW, Sammei MD, Lin H, et ai. Associations of Hormones and Menopausai Status With Depressed Mood in Women With No History of Depression. Arch Gen Psychiatry 2006;63:375-82.
  10. Morrison PM, Kaiian MJ, Ten Have T, et ai. Lack of efficacy of estradioi for depression in postmenopausai women: a randomized, controiied triai. Psychiatry 2004;55:406-12.
  11. Grady D, Yaffe K, Kristof M, et ai. Effect of postmenopausai hormone theraphy on cognitive function: the Heart and Estrogen/ progestin Repiacement Study. Am J Med 2002; 113:543-48.
  12. Henderson VW. Estrogen-containing hormone therapy and Aizheimer's disease risk: Understanding discrepant inferences from observationai and experimentai research. Neuroscience 2006;138:1031-39.
  13. Henderson VW, Benke KS, Green RC, et ai. Postmenopausai hormone therapy and Aizheimer's disease risk: lnteraction with age. J Neuroi Neurosurg Psychatry 2005;76:103-5.
  14. Hogervorst E, Wiiiiams J, Budge M, et ai. The nature of the effect of femaie gonadai hormone repiacement therapy on cognitive function in post-menopausai women: a meta-anaiysis. Neuroscience 2000; 101:485-512.
  15. Kang JH, Weuve J, Grodstein F. Postmenopausai hormone therapy and risk of cognitive deciine in community-dweiiing aging women. Neuroiogy 2004;63:101-07.
  16. Ford DE, Cooper-Patrick L. Sieep disturbances and mood disorders: An epidemioiogic perspective. Depress Anxiety 2001; 14:3-6.
  17. Lebrun CE, van der Schouw YT, de Jong FH, et ai. Endogenous Oestrogens Are Reiated to Cognition in Heaithy Eideriy Women. Ciin Endocrinoi (Oxf) 2005;63:50-5.
  18. MacLennan AH, Henderson VW, Paine BJ, et ai. Hormone therapy, timing of initiation, and cognition in women oider than 60 years: the REMEMBER piiot study. Menopause 2006;13:28-36.
  19. Barrett-Connor E, Laughiin GA. Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausai women: evidence from epidemioiogic studies and ciinicai triais. Semin Reprod Med 2009;27(3):275-82.
  20. Zandi PP, Carison MC, Piassman BL, et ai. Hormone repiacement therapy and incidence of Aizheimer disease in oider women: the Cache County Study. JAMA 2002;288:2123-29.
  21. Сметник В.П., Ильина Л.М. В кн.: Медицина климактерия. Ярославль, 2006. С. 349-415.
  22. Kuikarni J. Oestrogen - a new treatment approach for schizophrenia? Med J Austr 2009;190(4):37-8.
  23. Hafner H. Gender Differences in Schizophrenia. ln Estrogen effects in psychiatric disorders. / Ed. Bergemann N, Riecher-Russier A. Vienna: Springer-Veriag 2005;53-94.
  24. Loffier W, Hafner H, Fatkenheuer B, et ai. Vaiidation of Danish case register diagnosis for schizophrenia. Acta Psychiatr Scand 1994;90:196-203.
  25. Kuikarni J, de Casteiia A, Riedei A, et ai. Estrogen -a potentiai treatment for schizophrenia. Schizophr Res 2001;48:137-44.
  26. Erei CT, Brincat M, Gambacciani M, et ai. EMAS position statement: Managing the menopause in women with epiiepsy. Maturitas 2010;66 (3):327-28.
  27. Harden CL, Herzog AG, Nikoiov BG, et ai. Hormone repiacement therapy in women with epiiepsy: a randomized, doubie-biind, piacebo-controiiedstudy. Epiiepsia 2006;47:1447-51.
  28. Lambrinoudaki l, Brincat M, Erei T, et ai. EMAS position statement: Managing obese postmenopausai women. Maturitas 2010;66:323-26.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies