Rol' defitsita vitamina D v formirovanii osteopenicheskogo sindroma u molodykh zhenshchin s ozhireniem i normal'noy massoy tela


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Abstract

The results of studies assessing bone mineral density in obese people are rather inconsistent. The present study was aimed to the identification of indicators of mineralization of the skeleton in women with different body mass to clarify the contribution of vitamin D deficiency in the formation of osteopenic syndrome. The study involved 204 women aged 30 to 52 years (mean age 46.20±0.54 years). Reduced bone mineral density (BMD) at the lumbar spine or proximal femur was found in 38 women (18.6%). It has been established that the 25 (OH) D levels (R2=0.25, р=0.011) and parathyroid hormone levels (R2=0.15, р=0.037) provided the greatest effect on the BMD of the lumbar spine (in women under the age of 40 years); the bone mineral density of proximal femur depended on the body mass index (R2=0.21, р=0.016), waist circumference (R2=0.30, р=0.005), amount of adipose tissue (R2=0.28, р=0.006) and serum leptin levels (R2=0.26, р=0.043), regardless of the women age. Thus, the study showed that the amount of body fat, vitamin D deficiency and high leptin levels play an important role in bone remodeling in young women.

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