The use of Lactobacillus rhamnosus GG-containing probiotics for the prevention of atopic dermatitis in children


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

There are qualitative and quantitative differences in the composition of the intestinal microflora in healthy infants and in children with atopic dermatitis. These data gave an impulse to development of concept that the beneficial bacteria in the intestinal microflora, called probiotics, can restore intestinal homeostasis and prevent allergies or decrease its manifestation through interaction with the immune cells in the intestine. Not all probiotic strains have the same properties. The article summarizes the current understanding of the possibilities of prevention of atopic dermatitis in children using Lactobacillus rhamnosus GG. A review of research on the prevention of atopic dermatitis in children in the prenatal and postnatal periods is presented.

Full Text

Restricted Access

About the authors

K. N Monakhov

First St. Petersburg Medical University n.a. Acad. I.P. Pavlov

Email: knmonakhov@mail.ru
MD, Prof. Department of Dermatovenereology with the Clinic

D. K Dombrovskaya

First St. Petersburg Medical University n.a. Acad. I.P. Pavlov

Department of Family Medicine

E. V Nazarenko

First St. Petersburg Medical University n.a. Acad. I.P. Pavlov

Department of Dermatovenereology with the Clinic

References

  1. Asher M.I., Montefort S., Björkstän B., Lai C.K., Strachan D.P., Weiland S.K., Williams H. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733-43.
  2. Атопический дерматит и инфекции кожи у детей: диагностика, лечение и профилактика: научно-практическая программа / Под ред. Д.С. Коростовцева. М., 2004. 47 с.
  3. Pistiner M., Gold D.R., Abdulkerim H., Hoffman E., Celedon J.C. Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy. J. Allergy Clin. Immunol. 2008;122:274-79.
  4. Ly N.P., Ruiz-Pérez B., Onderdonk A.B., Tzianabos A.O., Litonjua A.A., Liang C., Laskey D., Delaney M.L., DuBois A.M., Levy H., Gold D.R., Ryan L.M., Weiss ST., Celedon J.C. Mode of delivery and cord blood cytokines: a birth cohort study. Clin. Mol. Allergy. 2006;4:13.
  5. Sansonetti P.J., Medzhitov R. Learning tolerance while fighting ignorance. Cell. 2009;138(3):416-20.
  6. Björkstén B., Sepp E., Julge K., Voor T., Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J. Allergy Clin. Immunol. 2001;108:516-20.
  7. Gourbeyre P., Denery S., Bodinier M. Probiotics, prebiotics, and synbiotics: Impact on the gut immune system and allergic reactions. J. Leukoc. Biol. 2011;89:685-95.
  8. Vighi G., Marcucci F., Sensi L., Di Cara G., Frati F. Allergy and the gastrointestinal system. Clin. Exp. Immun. 2008;153:3-6.
  9. Özdemir Ö. Various effects of different probiotic strains in allergic disorders: An update from laboratory and clinical data. Clin. Exp. Immun. 2010;160:295-304.
  10. Özdemir Ö. Gut flora development in infancy and its effect on immune system (in Turkish). Çocuk Enf. Derg. J. Pediatr. Inf. 2009;3:202-3.
  11. Holzapfel W.H., Haberer P., Geisen R., Björkroth J., Schillinger U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am. J. Clin. Nutr. 2001; 73(2):365-73.
  12. Gourbeyre P., Denery S., Bodinier M. Probiotics, prebiotics, and synbiotics: Impact on the gut immune system and allergic reactions. J. Leukoc. Biol. 2011;89:685-95.
  13. Gorbach S.L., Goldin B.R. Lactobacillus strains and methods of selection. US Patent. №. 4839281.
  14. Conway P.L., Gorbach S.L., Goldin B.R. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J. Dairy. Sci. 1987;70(1):1-12.
  15. Rosenfeldt V., Benfeldt E., Valerius N.H., Paerregaard A., Michaelsen K.F Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J. Pediatr. 2004;145(5):612-16.
  16. Majamaa H., Isolauri E. Probiotics: a novel approach in the management of food allergy. J. Allergy. Clin. Immunol. 1997;99(2):179-85.
  17. Research suggests potential role for probiotics in treating allergy. Infect. Dis. Childr. 2003;3:72.
  18. Kalliomaki M., Isolauri E. Role of intestinal flora in the development of allergy. Curr. Opin. Allergy. Clin. Immunol. 2003;3(1):15-20.
  19. Berni Canani R., Ruotolo S., Discepolo V., Troncone R. The diagnosis of food allergy in children. Curr. Opin. Pediatr. 2008;20:584-89.
  20. Isolauri E., Arvola T., Sutas Y., Moilanen E., Salminen S. Probiotics in the management of atopic eczema. Clin. Exp. Allergy 2000; 30:1604-10.
  21. Gordon B.R. The allergic march: Can we prevent allergies and asthma? Otolaryngol. Clin. North Am. 2011;44:765-77.
  22. Lahtinen S.J., Boyle R.J., Kivivuori S., Oppedisano F., Smith K.R., Robins-Browne R., Salminen S.J., Tang M.L. Prenatal probiotic administration can influence Bifidobacterium microbiota development in infants at high risk of allergy. J. Allergy Clin. Immunol. 2009;123:499-501.
  23. Rautava S., Kalliomäki M., Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J. Allergy Clin. Immunol. 2002;109:119-21.
  24. Boyle R.J., Ismail I.H., Kivivuori S., Licciardi P.V., Robins-Browne R.M., Mah L.J., Axelrad C., Moore S., Donath S., Carlin J.B., Lahtinen S.J., Tang M.L. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy. 2011;66:509-16.
  25. Böttcher M.F., Abrahamsson T.R., Fredriksson M., Jakobsson T., Björkstén B. Low breast milk TGF-beta2 is induced by Lactobacillus reuteri supplementation and associates with reduced risk of sensitization during infancy. Pediatr. Allergy Immunol. 2008;19:497-504.
  26. Prescott S.L., Wickens K., Westcott L., Jung W., Currie H., Black P.N., Stanley T.V., Mitchell E.A., Fitzharris P., Siebers R., Wu L., Crane J. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin. Exp. Allergy. 2008;38:1606-14.
  27. Kuitunen M., Kukkonen A.K., Savilahti E. Impact of maternal allergy and use of probiotics during pregnancy on breast milk cytokines and food antibodies and development of allergy in children until 5 years. Int. Arch. Allergy Immunol. 2012;159:162-70.
  28. Kopp M.V., Hennemuth I., Heinzmann A., Urbanek R. Randomized, Double-Blind, Placebo-Controlled Trial of Probiotics for Primary Prevention: No Clinical Effects of Lactobacillus GG Supplementation. Pediatrics. 2008;121(4):850-56.
  29. Wickens K., Black P.N., Stanley T.V., Mitchell E., Fitzharris P., Tannock G.W., Purdie G., Crane J. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J. Allergy Clin. Immunol. 2008;122:788-94.
  30. Wickens K., Black P., Stanley T.V., Mitchell E., Barthow C., Fitzharris P, Purdie G., Crane J. A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clin. Exp. Allergy. 2012;42:1071-79.
  31. Nermes M., Kantele J.M., Atosuo T.J., Salminen S., Isolauri E. Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis. Clin. Exp. Allergy. 2010;41:370-77.
  32. Laitinen K., Kalliomäki M., Poussa T., Lagström H., Isolauri E. Evaluation of diet and growth in children with and without atopic eczema: followup study from birth to 4 years. Br. J. Nutr. 2005;94(4):565-74.
  33. Tanaka A., Jung K., Benyacoub J., Prioult G., Okamoto N., Ohmori K., Blum S., Mercenier A., Matsuda H. Oral supplementation with Lactobacillus rhamnosus CGMCC 1.3724 prevents development of atopic dermatitis in NC/NgaTnd mice possibly by modulating local production of IFN-y. Exp. Dermatol. 2009;18(12):1022-27.
  34. Dotterud C.K., Storro O., Johnsen R., Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial Br. J. Dermatol. 2010;163(3):616-23.
  35. Abrahamsson T.R., Jakobsson T., Böttcher M.F., Fredrikson M., Jenmalm M.C., Björkstén B., Oldaeus G. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J. Allergy Clin. Immunol. 2007;119(5):1174-80.
  36. Kalliomäki M., Salminen S., Arvilommi H., Kero P., Koskinen P., Isolauri E. Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet. 2001;357:1076-79.
  37. Doege K., Grajecki D., Zyriax B.C., Detinkina E., Zu Eulenburg C., Buhling K.J. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood -a meta-analysis. Br. J. Nutr. 2011;26:1-6.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies