SAFETY OF APPLICATION OF SHORT COURSES OF GLUCOCORTICOSTEROIDS: LITERATURE REVIEW


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Abstract

The literature review is devoted to the safety of short courses of glucocorticosteroids (GCS) in children. An analysis of the literature has shown that short courses of treatment with GCS are characterized by a satisfactory safety profile in general. The most common side effects of GCS when used from 7 to 14 days include dyspepsia (nausea, vomiting), behavioral and sleep disorders. In most cases, these side effects cause withdrawal of GCS in children. The most dangerous, in terms of prognosis, can be the use of systemic GCS at the prodromal stage of varicella. Long-term use of GCS (courses more than 2 months) is associated with both suppression of adrenal cortex function and immunosuppression. Studies show that treatment with short courses of systemic GCS (orally 1 to 2 mg/ kg/day of prednisolone or prednisone for 3-7 days) does not cause these effects, even if they are used several times in one year. However, an increase in the duration of treatment with systemic GCS beyond 7 days, according to several studies, increases the risk of serious side effects.

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About the authors

A. M Suleymanova

FSAI "National Scientific and Practical Center for Children's Health" of RMH

T. V Kulichenko

FSAI "National Scientific and Practical Center for Children's Health" of RMH

Email: Tkulichenko@yandex.ru
MD, Prof. RAS, Head of the Department of Emergency Pediatrics

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