DIAGNOSIS AND TREATMENT OF THE GUILLAIN-BARRE SYNDROME IN CHILDREN: EXPERT'S OPINION

The article considers the diagnosis and treatment of the main clinical variants of Guillain-Barre syndrome (GBS) in children - acute inflammatory demyelinating polyneuropathy, acute motor axonal neuropathy, and acute motor-sensory axonal neuropathy. The emphasis is placed on the clinical manifestations of GBS in childhood, the features of motor and sensory disorders, the importance of distinguishing three timeframes of the disease; the additional necessary diagnostic approaches (cerebrospinal fluid analysis and electromyography) are described. From modern positions, pathogenetic methods of treatment are considered - immunotherapy with intravenous standard human immunoglobulin (IVIG) and plasmapheresis. The advantages of therapy with 10% IVIG are presented: high clinical efficacy, rapid onset of action, good tolerability, multicomponent mechanism of action with directed points of application, possibility of use in patients of different age groups - from infant to adult patient). A short transcript and a resolution of the Roundtable «Organization of medical care for children with Guillain-Barre syndrome», which was held on June 8, 2018 in St. Petersburg in the framework of the VIII Baltic Congress on Pediatric Neurology, is also presented.

Cuillain-Barre syndrome, acute inflammatory demyelinating polyneuropathy, acute motor axonal neuropathy, acute motor-sensory axonal neuropathy, electromyography, therapy with intravenous standard human immunoglobulin, plasmapheresis