Prospects for the use of metronidazole+miconazole in the treatment of mixed vaginal infections

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Abstract

The review presents the prospects for the use of a combination of metronidazole and miconazole in the treatment of mixed vaginal infections with an emphasis on the most common pathogens of this pathology and possible complications that occur against the background of monocomponent therapy regimens. Taking into account intravaginal use, the mechanism of the pharmacological action of medicinal components that are part of combined preparations is discussed. The pharmacodynamic and pharmacokinetic mechanisms of action of metronidazole and miconazole are analyzed.

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About the authors

Ilya A. Kulikov

I.M. Sechenov First Moscow State Medical University (Sechenov University); V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Author for correspondence.
Email: ginkulikov@yandex.ru
ORCID iD: 0000-0003-2499-4727
Scopus Author ID: 57200074824

Cand. Sci. (Med.), Associate Professor

Russian Federation, Moscow; Moscow

I. A. Apolikhina

I.M. Sechenov First Moscow State Medical University (Sechenov University); V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: ginkulikov@yandex.ru
ORCID iD: 0000-0001-7529-980X
Scopus Author ID: 8656342200
Russian Federation, Moscow; Moscow

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