Prospects for the use of metronidazole+miconazole in the treatment of mixed vaginal infections

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The review presents the prospects for the use of a combination of metronidazole and miconazole in the treatment of mixed vaginal infections with an emphasis on the most common pathogens of this pathology and possible complications that occur against the background of monocomponent therapy regimens. Taking into account intravaginal use, the mechanism of the pharmacological action of medicinal components that are part of combined preparations is discussed. The pharmacodynamic and pharmacokinetic mechanisms of action of metronidazole and miconazole are analyzed.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Ilya Kulikov

I.M. Sechenov First Moscow State Medical University (Sechenov University); V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Хат алмасуға жауапты Автор.
Email: ginkulikov@yandex.ru
ORCID iD: 0000-0003-2499-4727
Scopus Author ID: 57200074824

Cand. Sci. (Med.), Associate Professor

Ресей, Moscow; Moscow

I. Apolikhina

I.M. Sechenov First Moscow State Medical University (Sechenov University); V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: ginkulikov@yandex.ru
ORCID iD: 0000-0001-7529-980X
Scopus Author ID: 8656342200
Ресей, Moscow; Moscow

Әдебиет тізімі

  1. Gynecology: national guidelines. Ed. by G.M. Savelieva, G.T. Sukhikh, V.N. Serov, V.E. Radzinsky, I.B. Manukhin. 2nd ed., revised. and additional. M., 2022. 1008 p. (In Russ.).
  2. Zong X.N., Feng Y.Z., Bai H.H., et al. Analysis of vaginal microecology in 23 181 cases of the gynecological female outpatients. Zhonghua Fu Chan Ke Za Zhi. 2023;58(3):191–97. Chinese. doi: 10.3760/cma.j.cn112141-20221212-00754.
  3. Obstetrics: national guidelines. Ed. by G.M. Savelieva, G.T. Sukhikh, V.N. Serov, V.E. Radzinsky. 2nd ed., revised. and additional. M., 2022. 1080 p. (In Russ.).
  4. Jia Q., Yu F., Ding Y., et al. Investigation and Analysis of 49343 Case Women’s Vaginal Microecology. Iran J. Public. Health. 2022;51(7):1611–17. doi: 10.18502/ijph.v51i7.10095.
  5. Podzolkova N.M., Sozaeva L.G. Vulvovaginal infections in obstetrics and gynecology. Diagnosis, treatment, rehabilitation. M., 2020. 160 p. (In Russ.). doi: 10.33029/9704-5582-1-VAG-2020-1-160.
  6. Apolikhina I.A., Gorbunova E.A., Efendieva Z.N. Modern possibilities in the treatment of mixed and aerobic vaginitis. Meditsinskii sovet. 2022;16(5):137–43. (In Russ.). doi: 10.21518/2079-701X-2022-16-5-137-143.
  7. Shaposhnikova E.V. Modern approaches to the treatment of vulvovaginitis of mixed etiology in women during pregnancy. Russkii meditsinskii zhurnal. Mat’ i ditya. 2021;4(1):5–11. (In Russ.). doi: 10.32364/2618-8430-2021-4-1-5-11.
  8. Tazina T.V. Modern approach to the treatment of mixed vulvovaginal infections. Russkii meditsinskii zhurnal. Mat’ i ditya. 2021;4(2):144–48. (In Russ.). doi: 10.32364/2618-8430-2021-4-2-144-148.
  9. Bondarenko K.R. Cervical-vaginal mixed infections in gynecology: unresolved issues of therapy. Russkii meditsinskii zhurnal. Mat’ i ditya. 2019;2(3):194–99. (In Russ.).
  10. Clinical recommendations «Bacterial vaginosis». All-Russian public organization «Russian Society of Dermatovenereologists and Cosmetologists». Ministry of Health of the Russian Federation, 2022. (In Russ.).
  11. Borovikov I.O., Kutsenko I.I., Bulgakova V.P. Mixed nonspecific infectious diseases of the vagina: experience of local therapy. Russkii meditsinskii zhurnal. Mat’ i ditya. 2020;3(4):221–27. (In Russ.). doi: 10.32364/2618-8430-2020-3- 4-221-227.
  12. Nazarova N.M., Nekrasova M.E., Dovletkhanova E.R., Abakarova P.R. Vaginitis and cervicitis: the choice of an effective method of therapy (literature review). Meditsinskii sovet. 2020;(3):17–23. (In Russ.). doi: 10.21518/2079-701X-2020-3-17-23.
  13. Tayah D.Y., Eid A.M. Development of miconazole nitrate nanoparticles loaded in nanoemulgel to improve its antifungal activity. Saudi Pharm. J. 2023;31(4):526–34. (In Russ.)]. doi: 10.1016/j.jsps.2023.02.005.
  14. Prilepskaya V.N., Abakarova P.R., Donnikov A.E. Vulvovaginitis of mixed etiology and real clinical practice. Gynekologiya=Gynecology. 2020;22(4):82–7. (In Russ.). doi: 10.26442/20795696.2020.4.200307.
  15. Treatment regimens. Obstetrics and gynecology. Ed. by V.N. Serov, editor-compiler I.I. Baranov. 3rd ed., corrected and enlarged. M., 2021. 368 p. (In Russ.).
  16. Drug provision of clinical protocols. Obstetrics and gynecology. Ed. by V.E. Radzinsky. M., 2019. 288 p. (In Russ.).
  17. Mikhanoshina N.V., Priputnevich T.V., Grigoryan I.E. Vaginitis and vaginosis: approaches to diagnosis and treatment in the light of current clinical guidelines. Akusherstvo i ginekologiya=Obstetrics and Gynecology. 2022;11:172–78. (In Russ.). doi: 10.18565/aig.2022.11.172-178.
  18. Kedrova A.G. Rational pharmacotherapy of the main diseases of the vagina. Gynekologiya=Gynecology. 2014;16(1):123–26. (In Russ.).
  19. Clinical pharmacology. Obstetrics. Gynecology. Barren marriage. Ed. by V.E. Radzinsky, E.V. Shih. 2nd ed., revised and enlarged. M., 2021. (In Russ.).

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Bionika Media, 2023

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>