Nail pathology: clinical and laboratory aspects, issues of resistance to antimycotics

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The article discusses modern aspects of the formation of resistance of mycotic infections to antifungal drugs, which is one of the reasons for the loss of the expected clinical efficacy of therapy. Factors such as the appointment of antimycotics without laboratory tests necessary to confirm or exclude the fungal nature of nail damage, misinterpretation of diagnostic test results, irrational treatment tactics, and self-treatment contribute to a decrease in the sensitivity of pathogens of superficial skin mycosis and onychomycosis. Changes in the nail apparatus are characteristic not only for fungal invasion, but also for onychodystrophies and a number of other nosologies. The similarity of clinical manifestations of onychopathy of various etiologies creates difficulties in differential diagnosis and can lead to therapeutic errors. The article presents the main clinical characteristics of nail pathology of various origins: onychomycosis (a chronic fungal infection of the nails that requires etiotropic therapy with antifungal agents), and onychodystrophy (different non-infectious changes in the nail plate, in which the use of antimycotics is not indicated). Modern methods of laboratory and instrumental diagnosis of onychomycosis are described, aspects of differential diagnosis of onychomycosis with all types of non-infectious dystrophies of the nail plates, including nail lesions in diseases such as psoriasis, lichen planus, eczema, are discussed.

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作者简介

O. Pozdnyakova

Novosibirsk State Medical University

Email: obnemchaninova@mail.ru
ORCID iD: 0000-0003-1389-1001
俄罗斯联邦, Novosibirsk

Olga Nemchaninova

Novosibirsk State Medical University

编辑信件的主要联系方式.
Email: obnemchaninova@mail.ru
ORCID iD: 0000-0002-5961-6980

Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology

俄罗斯联邦, Novosibirsk

I. Sergeeva

Novosibirsk National Research State University

Email: obnemchaninova@mail.ru
ORCID iD: 0000-0003-1748-8957
俄罗斯联邦, Novosibirsk

A. Chasnyk

Novosibirsk National Research State University

Email: obnemchaninova@mail.ru
ORCID iD: 0009-0002-3663-1827
俄罗斯联邦, Novosibirsk

T. Reshetnikova

Novosibirsk State Medical University

Email: obnemchaninova@mail.ru
ORCID iD: 0000-0002-6156-0875
俄罗斯联邦, Novosibirsk

参考

  1. Грачева Н.Н., Лебедев А.В. Оценка процессов отпуска из аптечных организаций рецептурных лекарственных препаратов. Наука, образование, инновации: апробация результатов исследований: Материалы Международной (заочной) научно-практической конференции. 2020. С. 768–76. [Gracheva N.N., Lebedev A.V. Evaluation of processes for dispensing prescription drugs from pharmacies. Science, education, innovation: approbation of research results: Proceedings of the International (correspondence) scientific and practical conference. 2020. Р. 768–76. (In Russ.)].
  2. Croxtall J.D., Plosker G.L. Sertaconazole: A review of its use in the management of super ficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339–59. doi: 10.2165/00003495-200969030-00009.
  3. Хамаганова И.В., Карамова А.Э., Шекрота А.Г., Макушина З.В. Применение сертаконазола в лечении микроспории гладкой кожи. Клиническая дерматология и венерология. 2010;8(3):32–6. [Khamaganova I.V., Karamova A.E., Shekrota A.G., Makushina Z.V. Application of sertaconazole for the treatment of smooth skin microsporia. Klinicheskaya Dermatologiya i Venerologiya. 2010;8(3):32–6. (In Russ.)]
  4. Соколова Т.В., Малярчук А.П., Малярчук Т.А. Результаты многоцентрового исследования по изучению поверхностных микозов кожи в регионах Российской Федерации и оценке эффективности их лечения сертаконазолом. Клиническая дерматология и венерология. 2013;11(5):28–39. [Sokolova T.V., Maliar- chuk A.P., Maliarchuk T.A. Results of a multicenter trial to investigate the incidence of superficial mycoses in the regions of the Russian Federation and to evaluate the efficiency of their treatment with sertaconazole. Klinicheskaya Dermatologiya i Venerologiya. 2013;11(5):28–39. (In Russ.)]
  5. Иванова Л.В., Баранцевич Е.П., Шляхто Е.В. Резистентность грибов-патогенов к антимикотикам (обзор). Проблемы медицинской микологии. 2011;13(1):14–7. [Ivanova L.V., Barantsevich E.P., Shlyakhto E.V. Resistance of pathogenic fungi to antimycotics (review). Problemy meditsinskoi mikologii. 2011;13(1):14–7. (In Russ.)].
  6. Maskan Bermudez N., Rodriguez-Tamez G., Perez S., Tosti A. Onychomycosis: Old and New. J Fungi (Basel). 2023;12;9(5):559. doi: 10.3390/jof9050559.
  7. Цыкин А.А., Сирмайс Н.С. Ониходистрофии: клиника, диагностика, лечение. Русский медицинский журнал. 2015;9:508. [Tsykin A.A., Sirmais N.S. Onychodystrophy: clinic, diagnosis, treatment. Russkii meditsinskii zhurnal. 2015;9:508. (In Russ.)].
  8. Сергеев А.Ю., Бурова С.А., Касихина Е.И. Дерматомикозы в эпоху пандемии. Иммунопатология, аллергология, инфектология. 2021;1:79–96. [Sergeev A.Yu., Burova S.A., Kasikhina E.I. Dermatomycoses in the era of pandemic. Immunopatologiya, allergologiya, infektologiya. 2021;1:79-96. (In Russ.)]. doi: 10.14427/jipai.2021.1.79.
  9. Mukherjee P.K., Leidich S.D., Isham, N., Leitner I., Ryder N.S., Ghannoum M.A. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob. Agents Chemother. 2003;47:82–6. doi: 10.1128/aac.47.1.82-86.2003.
  10. Favre B., Ghannoum M.A., Ryder N.S. Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates. Med Mycol. 2004;42(6):525–29. 529. doi: 10.1080/13693780410001661482.
  11. Osborne C.S., Leitner I., Hofbauer B., et al. Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrob. Agents Chemother. 2006;50(6):2234–36. doi: 10.1128/aac.01600-05.
  12. Digby S.S., Hald M., Arendrup M.C., et al. Darier Disease Complicated by Terbinafine-resistant Trichophyton rubrum: A Case Report. Acta Derm Venereol. 2017;97:139–40. doi: 10.2340/00015555-2455.
  13. Salehi Z., Shams-Ghahfarokhi M., Razzaghi-Abyaneh M. Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates. Eur J Clin Microbiol Infect Dis. 2018;37:1841–46. doi: 10.1007/s10096-018-3317-4.
  14. Bishnoi A., Vinay K., Dogra S. Emergence of recalcitrant dermatophytosis in India. Lancet Infect Dis. 2018;18:250–51. doi: 10.1016/S1473-3099(18)30079-3.
  15. Sonthalia S., Agrawal M., Goldust M., et al. Antifungal therapeutic failures in India: An important issue being overlooked. Lancet Infect Dis. 2018;18:1181–82. doi: 10.1016/S1473-3099(18)30593-0.
  16. Moreno-Sabater A., Normand A.-C., Bidaud A.-L., et al. Terbinafine Resistance in Dermatophytes: A French Multicenter Prospective Study. J Fungi. 2022;8(3):220. doi: 10.3390/jof8030220.
  17. Saunte D.M.L., Pereiro-Ferreiros M., Rodriguez-Cerdeira C., et al. Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic. J Eur Acad Dermatol Venereol. 2021;35(7):1582–86. doi: 10.1111/jdv.17241.
  18. Astvad K.M.T., Hare R.K., Jorgensen K.M., et al. Increasing Terbinafine Resistance in Danish Trichophyton Iso-lates 2019–20. J Fungi 2022;8:150. doi: 10.3390/jof8020150.
  19. Suzuki S., Mano Y., Furuya N., Fujitani K. Disco- very of terbinafine low susceptibility tricho-phyton rubrum strain in Japan. Biocontrol Sci. 2018;23:151–54. doi: 10.4265/bio.23.151.
  20. Gupta A.K, Venkataraman M. Antifungal resistance in superficial mycoses. J Dermatolog Treat. 2022;33(4):1888–95. doi: 10.1080/09546634.2021.1942421.
  21. Бухарева В.Ю., Беляев В.С. Резистентность возбудителей дерматомикозов к антимикотикам. Молодежь, наука, медицина: материалы 68-й Всероссийской межвузовской студенческой научной конференции с международным участием. Тверь. 2022. C. 201–4. [Bukhareva V.Yu., Belyaev V.S. Resistance of pathogens of dermatomycoses to antimycotics. Youth, Science, Medicine: Proceedings of the 68th All-Russian Interuniversity Student Scientific Conference with International Participation. Tver. 2022. P. 201–4. (In Russ.)].
  22. Всероссийский центр изучения общественного мнения [Электронный ресурс]: аналитический обзор. Тяжкий труд, бедность и старость: три причины болезней России. 2019. [All-Russian Center for the Study of Public Opinion [Electronic resource]: analytical review. Hard work, poverty and old age: three causes of Russia’s illnesses. M., 2019. (In Russ.)]. URL: https://wciom.ru/analytical-reviews/analiticheskii-obzor/tyazhkij-trud-bednost-i-starost-tri- prichiny-boleznej- v-rossii
  23. Baracaldo-Santamaria D., Trujillo-Moreno M.J., Perez-Acosta A.M. et al. Definition of self-medication: a scoping review. Ther Adv Drug Saf. 2022;13:20420986221127501. doi: 10.1177/20420986221127501.
  24. Егорова Е.А. Шейхмамбетова Л.Н., Бекиро-ва Э.Ю. Маркетинговый анализ ассортимента противогрибковых препаратов для местного применения на фармацевтическом рынке Российской Федерации. Современная организация лекарственного обеспечения. 2021;8(1):7–13. [Egorova E.A. Sheikhmambetova L.N., Bekirova E.Yu. Marketing analysis of the range of antifungal drugs for local use in the pharmaceutical market of the Russian Federation. Sovremennaya organizatsiya lekarstvennogo obespecheniya. 2021;8(1):7–13. (In Russ.)]. doi: 10.30809/solo.1.2021.1.
  25. Торшина И. Е. Онихомикоз и ониходистрофии: дифференциальная диагностика и рациональная терапия. Consilium Medicum. 2020;22(7):49–53. [Torshina I. E. Onychomycosis and onychodystrophy: differential diagnosis and rational therapy. Consilium Medicum. 2020;22(7):49–53. (In Russ.)]. doi: 10.26442/20751753.2020.7.200290.
  26. Чеботарев В.В., Одинец А.В., Шиханова Е.Н. Онихомикоз и ониходистрофии: дифференциальная диагностика. Успехи медицинской микологии. 2020;21:85–91. [Chebotarev V.V., Odinets A.V., Shikhanova E.N. Onychomycosis and onychodystrophy: differential diagnosis. Uspekhi meditsinskoi mikologii. 2020;21:85–91. (In Russ.)].
  27. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов». Клинические рекомендации. Микозы кожи головы, туловища, кистей и стоп. 2020 (проект). [All-Russian public organization «Russian Society of Dermatovenereologists and Cosmetologists». Clinical guidelines. Mycosis of the scalp, trunk, hands and feet. 2020 (project). (In Russ.)]. URL: https://www.cnikvi.ru/docs/clinic_recs/klinicheskie-rekomendatsii-2019-2020/
  28. Hasche E.G., Podda M. Onychomykose: Konzepte for die Praxis. Hautarzt. 2018;69:718-725. doi: 10.1007/s00105-018-4255-x.
  29. Ruben B.S. Pathology of the Nail Unit. Dermatol Clin. 2021;39(2):319–36. doi: 10.1016/j.det.2020.12.009.
  30. Leung A.K.C., Lam J.M., Leong K.F. et al. Onychomycosis: An Updated Review. Recent Pat Inflamm Allergy Drug Discov. 2020;14(1):32–45. doi: 10.2174/1872213X13666191026090713.
  31. Хаитов К.Н., Абидов Х.А., Эргашева М.А. К вопросу распространенности микозов. Современные тенденции развития образования, науки и технологий: сборник научных трудов по материалам IX международной научно-практической конференции. 2019;121(23):111–13. [Khaitov K.N., Abidov Kh.A., Ergasheva M.A. On the issue of the prevalence of mycoses. Modern trends in the development of education, science and technology: a collection of scientific papers based on the materials of the IX International Scientific and Practical Conference. 2019;121(23):111–13. (In Russ.)].
  32. Gupta A.K., Venkataraman M., Shear N.H, Piguet V. Onychomycosis in children – review on treatment and management strategies. J Dermatolog Treat. 2022;33(3):1213–24. doi: 10.1080/09546634.2020.1810607.
  33. Gupta A.K., Summerbell R.C., Venkataraman M., Quinlan E.M. Nondermatophyte mould onychomycosis. J Eur Acad Dermatol Venereol. 2021;35(8):1628–41. doi: 10.1111/jdv.17240.
  34. Цыкин А.А., Ломоносов К.М. Онихомикоз: этиология, диагностика, клиника и лечение. Русский медицинский журнал. 2007;19:1371. [Tsykin A.A., Lomonosov K.M. Onychomycosis: etiology, diagnosis, clinic and treatment. Russkii meditsinskii zhurnal. 2007;19:1371. (In Russ.)].
  35. Соколова Т.В., Малярчук Т.А. Эпидемиология микозов стоп (обзор литературы). Эпидемиология и вакцинопрофилактика. 2015;1(80):70–4. [Sokolova T.V., Malyarchuk T.A. Epidemiology of Foot Mycoses (Literature Review). Epidemiologiya i vaktsinoprofilaktika. 2015;1(80):70–4. (In Russ.)].
  36. Петрасюк О.А. Новые подходы к комплексной терапии микозов стоп: Автореф. дис. канд. мед. наук. Екатеринбург, 2007. [Petrasyuk O.A. New approaches to the complex therapy of mycoses of the feet: Abstract of the thesis. Diss. Cand. of Med. Sciences. Ekaterinburg, 2007. (In Russ.)].
  37. Bramono K., Budimulja U. Epidemiology of onychomycosis in Indonesia: data obtained from three individual studies. Nippon Ishinkin Gakkai Zasshi. 2005;46(3):171–76. doi: 10.3314/jjmm.46.171.
  38. Кунакбаева Т.С. Микозы стоп в Казахстане (современные особенности клинического течения, терапия и профилактика): Автореф. дисc. д-ра мед. наук. Алматы; 2004. [Kunakbaeva T.S. Mycoses of the feet in Kazakhstan (modern features of the clinical course, therapy and prevention): Abstract of the thesis. diss. Dr. med. Sciences. Almaty; 2004. (In Russ.)].
  39. Brilhante R.S., Cordeiro R.A., Medrano D.J., et al. Onychomycosis in Ceara (Northeast Brazil): epidemiological and laboratory aspects. Mem. Inst. Oswaldo Cruz. 2005;100(2):131–35. doi: 10.1590/s0074-02762005000200005.
  40. Hay R.J., Baran R. Onychomycosis: a proposed revision of the clinical classification. J Am Acad Dermatol. 2011;65(6):1219–27. doi: 10.1016/j.jaad.2010.09.730.
  41. Lim S.S., Hui L., Ohn J., et al. Diagnostic accuracy of dermoscopy for onychomycosis: A systematic review. Front Med. 2022;9:1048913.
  42. Loser C.R., Nenoff P., Mainusch O., et al. Common diseases of the nail: Diagnosis and therapy. J Dtsch Dermatol Ges. 2021;19(12):1761–75. doi: 10.1111/ddg.14627.
  43. Корюкина Е.Б., Глоба Е.И., Головенко Н.А. и др. Современные аспекты диагностики и лечения ониходистрофий. Клиническая дерматология и венерология. 2020;19(3):373-380. [Koriukina E.B., Globa E.I., Golovenko N.A., et al. Modern aspects of diagnosis and treatment of onychodystrophy. Klinicheskaya Dermatologiya i Venerologiya. 2020;19(3):373–80. (In Russ.)]. doi: 10.17116/klinderma202019031373.
  44. Lee D.K., Lipner S.R. Optimal diagnosis and management of common nail disorders. Ann Med. 2022;54(1):694–712. doi: 10.1080/07853890.2022.2044511.
  45. Bloom A., Blanken B., Schlakman B., et al. A Review of Nail Dystrophies for the Practitioner. Adv Skin Wound Care. 2020;33(1):20–6. doi: 10.1097/01.ASW.0000613536.27194.3c.
  46. Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов». Клинические рекомендации. Псориаз. 2023. [All-Russian public organization «Russian Society of Dermatovenereologists and Cosmetologists». Clinical guidelines. Psoriasis. 2023. (In Russ.)]. URL: https://cr.minzdrav.gov.ru/schema/234_2
  47. Gupta M.K., Lipner S.R. Review of Nail Lichen Planus: Epidemiology, Pathogenesis, Diagnosis, and Treatment. Dermatol Clin. 2021;39(2):221–30. doi: 10.1016/j.det.2020.12.002.
  48. Ruben B.S. Pathology of the Nail Unit. Dermatol Clin. 2021;39(2):319–36. doi: 10.1016/j.det.2020.12.009.

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