No 6-2 (2014)

This study was aimed to the evaluation of the anti-inflammatory efficacy of combination of standard therapy of seasonal allergic rhinitis with the barrier preparation (Prevalin). The open perspective randomized comparative parallel-group study included 49 patients with moderate to severe seasonal allergic rhinitis caused by wormwood pollen sensitization. All patients were treated with intranasal glucocorticosteroids in combination with a non-sedating antihistamines, 30 patients additionally received Prevalin 4 times a day. The frequency and severity of symptoms during treatment, the need for drug therapy, standard laboratory parameters, the level of eosinophil cationic protein in serum and nasal contents were evaluated. The results showed that the use of Prevalin in addition to the standard pharmacotherapeutic complex promoted more rapid and effective suppression of disease symptoms, as well as support of pharmacological remission of the disease using a smaller volume of basic therapy. More rapid achievement of clinical effect was recorded against the background of a more effective suppression of allergic inflammation.

The article presents the modern approaches to the topical treatment of atopic dermatitis (AD). Selection of optimal topical treatment of AD is based on leading role of immune inflammation and the presence of other pathological changes (dry skin, hyperkeratosis, lichenification, secondary infection). The place of conventional drugs, topical corticosteroids, calcineurin inhibitors (pimecrolimus, tacrolimus) in therapy of AD is considered. The need for use of medical cosmetics is emphasized.

The upward trend in the prevalence of atopic dermatitis (AD), clinical manifestation in early age, as well as increased incidence of severe forms of the disease determine the great social health importance of this problem in pediatrics. Basis of complex, pathogenetically justified treatment of atopic dermatitis include topical anti-inflammatory therapy. Proper selection of external medicines and their rational use in accordance to the general principles of treatment contribute to achieving maximum therapeutic effect.

The article presents information on the etiology, pathogenesis, classification, clinical manifestation, diagnosis, treatment and prevention of allergic rhinitis (AR). According to the new version of ARIA (2008), the compliance to the principles of sequential therapy and individual approach, pathogenesis, complexity and the prevention of disease in the treatment of patients with AR is required. Strategy of combined background therapy, taking into account the characteristics of AR and comorbid diseases in individual patient, is optimal for patients with AR.

Article is devoted to the problem of clinical allergy - diagnosis and treatment of allergy to the venom of stinging insects - the most frequent type of insect allergens. The article highlights the issues of prevalence of allergic reactions to sting, discusses the classification of the order Hymenoptera. Discussed in detail features of the course, modern methods of diagnosis, therapy and prevention of allergy to the venom of stinging insects. Presented the guidance on the need to use epinephrine in anaphylaxis as a first-line drug.

Allergic rhinitis is one of the most pressing global health problems, characterized by steady growth in the number of cases and severe economic burden. Topical glucocorticosteroids are the drug of choice in the treatment of patients with allergic rhinitis. Mometasone furoate in the form of a nasal spray has the best safety profile and allows to control the symptoms of allergic rhinitis.